PRDX1 - Peroxiredoxin-1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
PRDX1 »  Peroxiredoxin-1   [ EC 1.11.1.15 ]
 
Protein also known as:  Thioredoxin-dependent peroxide reductase 2.
Gene name:  PRDX1
Family name: AhpC/TSA
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 101 1
GENE REF ISO

Function

 show evidences
Overview 
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Heme bindingdefinition[GO:0020037] silver  
  • IEAOrtholog Compara
Peroxidase activitydefinition[GO:0004601]  
1
  • IDAMGI
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Thioredoxin peroxidase activitydefinition[GO:0008379]  
1
  • IDABHF-UCL
GO biological process 
Cell proliferationdefinition[GO:0008283] silver  
  • IEAOrtholog Compara
Erythrocyte homeostasisdefinition[GO:0034101] silver  
  • IEAOrtholog Compara
Hydrogen peroxide catabolic processdefinition[GO:0042744]  
2
  • IDABHF-UCL
  • IDAMGI
Natural killer cell mediated cytotoxicitydefinition[GO:0042267] silver  
  • IEAOrtholog Compara
Regulation of NF-kappaB import into nucleusdefinition[GO:0042345] silver  
  • IEAOrtholog Compara
Regulation of stress-activated MAPK cascadedefinition[GO:0032872] silver  
  • IEAOrtholog Compara
Removal of superoxide radicalsdefinition[GO:0019430] silver  
  • IEAOrtholog Compara
Skeletal system developmentdefinition[GO:0001501]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.11.1.15: 2 R'-SH + ROOH R'-S-S-R' + H(2)O + ROH.  
  • CuratedUniProtKB
 
More information is available from:
  • PeroxiBase: 4501 [ Hs2CysPrx01 ]
Pathways 
According to KEGG, this protein belongs to the following pathway:
Peroxisome  hsa04146+5052  
Note 
The active site is the redox-active Cys-52 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-173-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin.  
  • CuratedUniProtKB
Inactivated upon oxidative stress by overoxidation of Cys-52 to Cys-SO(2)H and Cys-SO(3)H. Cys-SO(2)H is retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Antioxidant  definition   [KW-0049]
Oxidoreductase  definition   [KW-0560]
Peroxidase  definition   [KW-0575]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Peroxiredoxin_1
GenomeRNAi: 5052
PRO: PR:Q06830