PRDX1 - Peroxiredoxin-1 - human protein (Function)
 
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PRDX1 »  Peroxiredoxin-1   [ EC 1.11.1.15 ]
 
Protein also known as:  Thioredoxin-dependent peroxide reductase 2.
Gene name:  PRDX1
Family name: AhpC/TSA
Entry whose protein(s) existence is based on evidence at protein level
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1 134 1
GENE REF ISO

Function

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Overview 
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).  
1
  • UniProtKB
GO molecular function 
Heme bindingdefinition[GO:0020037] silver  
1
  • Ortholog Compara
Peroxidase activitydefinition[GO:0004601]  
1
  • MGI
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
Thioredoxin peroxidase activitydefinition[GO:0008379]  
1
  • BHF-UCL
GO biological process 
Cell proliferationdefinition[GO:0008283] silver  
1
  • Ortholog Compara
Erythrocyte homeostasisdefinition[GO:0034101] silver  
1
  • Ortholog Compara
Hydrogen peroxide catabolic processdefinition[GO:0042744]  
2
  • BHF-UCL
  • MGI
Natural killer cell mediated cytotoxicitydefinition[GO:0042267] silver  
1
  • Ortholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
1
  • UniProtKB KW
Regulation of NF-kappaB import into nucleusdefinition[GO:0042345] silver  
1
  • Ortholog Compara
Regulation of stress-activated MAPK cascadedefinition[GO:0032872] silver  
1
  • Ortholog Compara
Removal of superoxide radicalsdefinition[GO:0019430] silver  
1
  • Ortholog Compara
Retina homeostasisdefinition[GO:0001895]  
1
  • UniProtKB
Skeletal system developmentdefinition[GO:0001501]  
1
  • PINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.11.1.15: 2 R'-SH + ROOH R'-S-S-R' + H(2)O + ROH.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Peroxisome  hsa04146+5052  
According to Reactome, this protein belongs to the following pathway:
Detoxification of Reactive Oxygen Species  REACT_264249  
Note 
The active site is the redox-active Cys-52 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-173-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin.  
1
  • UniProtKB
Inactivated upon oxidative stress by overoxidation of Cys-52 to Cys-SO(2)H and Cys-SO(3)H. Cys-SO(2)H is retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized.  
1
  • UniProtKB
 

Keywords

Molecular function 
Antioxidant  definition   [KW-0049]
Oxidoreductase  definition   [KW-0560]
Peroxidase  definition   [KW-0575]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Peroxiredoxin_1
GenomeRNAi: 5052
PRO: PR:Q06830