ENPEP - Glutamyl aminopeptidase - human protein (Function)
 
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ENPEP »  Glutamyl aminopeptidase   [ EC 3.4.11.7 ]  (EAP)
 
Protein also known as:  Differentiation antigen gp160; CD antigen CD249.
Gene name:  ENPEP
Family name: Peptidase M1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.  
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  • UniProtKB
GO molecular function 
Aminopeptidase activitydefinition[GO:0004177]  
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  • UniProtKB
Metalloaminopeptidase activitydefinition[GO:0070006]  
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  • UniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
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  • InterPro 2 GO
GO biological process 
Angiogenesisdefinition[GO:0001525]  
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  • Ortholog Curator
Angiotensin catabolic process in blooddefinition[GO:0002005]  
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  • UniProtKB
Cell migrationdefinition[GO:0016477]  
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  • MGI
Cell proliferationdefinition[GO:0008283]  
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  • MGI
  • UniProtKB
Cell-cell signalingdefinition[GO:0007267]  
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  • UniProtKB
Glomerulus developmentdefinition[GO:0032835]  
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  • Ortholog Curator
Proteolysisdefinition[GO:0006508]  
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  • UniProtKB KW
Regulation of systemic arterial blood pressure by renin-angiotensindefinition[GO:0003081]  
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  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.11.7: Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide.  
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  • UniProtKB
It requires the following cofactor
 Zn(2+) : Binds 1 zinc ion per subunit.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Renin-angiotensin system  hsa04614+2028  
According to Reactome, this protein belongs to the following pathway:
Metabolism of Angiotensinogen to Angiotensins  REACT_147707  
 

Keywords

Molecular function 
Aminopeptidase  definition   [KW-0031]
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 2028
PRO: PR:Q07075