CXCL9 - C-X-C motif chemokine 9 - human protein (Function)
 
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CXCL9 »  C-X-C motif chemokine 9
 
Protein also known as:  Monokine induced by interferon-gamma (MIG).
Gene name:  CXCL9
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.  
1
  • UniProtKB
GO molecular function 
Chemokine activitydefinition[GO:0008009]  
1
  • UniProtKB
CXCR3 chemokine receptor bindingdefinition[GO:0048248]  
1
  • UniProtKB
Cytokine activitydefinition[GO:0005125]  
1
  • PINC
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
GO biological process 
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Cellular defense responsedefinition[GO:0006968]  
1
  • PINC
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
1
  • RefGenome
Chemotaxisdefinition[GO:0006935]  
1
  • UniProtKB
Defense responsedefinition[GO:0006952]  
1
  • PINC
Defense response to virusdefinition[GO:0051607] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • PINC
Immune responsedefinition[GO:0006955]  
1
  • RefGenome
Inflammatory responsedefinition[GO:0006954]  
1
  • UniProtKB KW
Positive regulation of cAMP metabolic processdefinition[GO:0030816]  
1
  • UniProtKB
Positive regulation of cAMP-mediated signalingdefinition[GO:0043950]  
1
  • UniProtKB
Positive regulation of leukocyte chemotaxisdefinition[GO:0002690]  
1
  • RefGenome
Positive regulation of myoblast differentiationdefinition[GO:0045663] silver  
1
  • Ortholog Compara
Positive regulation of myoblast fusiondefinition[GO:1901741] silver  
1
  • Ortholog Compara
Positive regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051281]  
1
  • UniProtKB
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • UniProtKB
Response to lipopolysaccharidedefinition[GO:0032496]  
1
  • RefGenome
Signal transductiondefinition[GO:0007165]  
2
  • PINC
T cell chemotaxisdefinition[GO:0010818]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+4283  
Cytokine-cytokine receptor interaction  hsa04060+4283  
Toll-like receptor signaling pathway  hsa04620+4283  
According to Reactome, this protein belongs to the following pathways:
Chemokine receptors bind chemokines  REACT_15344  
G alpha (i) signalling events  REACT_19231  
 

Keywords

Biological process 
Inflammatory response  definition   [KW-0395]
Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CXCL9
GenomeRNAi: 4283
PRO: PR:Q07325