BAX - Apoptosis regulator BAX - human protein (Function)
 
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BAX »  Apoptosis regulator BAX
 
Protein also known as:  Bcl-2-like protein 4 (Bcl2-L-4).
Gene name:  BAX
Family name: Bcl-2
Entry whose protein(s) existence is based on evidence at protein level
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1 114 8
GENE REF ISO

Function

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Overview 
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.  
7
  • UniProtKB
According to TCDB this is a transporter from family:
the bcl-2 (bcl-2) family  1.A.21.1.2  
GO molecular function 
BH3 domain bindingdefinition[GO:0051434]  
3
  • UniProtKB
  • HGNC
Channel activitydefinition[GO:0015267]  
1
  • BHF-UCL
Identical protein bindingdefinition[GO:0042802]  
13
  • IntAct
  • BHF-UCL
Lipid bindingdefinition[GO:0008289]  
1
  • HGNC
Protein bindingdefinition[GO:0005515]  
41
  • IntAct
  • UniProtKB
  • HGNC
  • BHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • HGNC
Protein homodimerization activitydefinition[GO:0042803]  
2
  • HGNC
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
2
  • HGNC
Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cdefinition[GO:0008635]  
1
  • HGNC
Activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaydefinition[GO:0097296] silver  
1
  • Ortholog Compara
Activation of signaling protein activity involved in unfolded protein responsedefinition[GO:0006987]  
1
  • ParkinsonsUK-UCL
Apoptotic mitochondrial changesdefinition[GO:0008637]  
1
  • HGNC
Apoptotic processdefinition[GO:0006915]  
3
  • UniProtKB
  • CACAO
  • ParkinsonsUK-UCL
Apoptotic process involved in embryonic digit morphogenesisdefinition[GO:1902263] silver  
1
  • Ortholog Compara
Apoptotic process involved in patterning of blood vesselsdefinition[GO:1902262] silver  
1
  • Ortholog Compara
Apoptotic signaling pathwaydefinition[GO:0097190]  
1
  • HGNC
B cell apoptotic processdefinition[GO:0001783]  
2
  • HGNC
B cell homeostasisdefinition[GO:0001782] silver  
1
  • Ortholog Compara
B cell homeostatic proliferationdefinition[GO:0002358] silver  
1
  • Ortholog Compara
B cell negative selectiondefinition[GO:0002352] silver  
1
  • Ortholog Compara
B cell receptor apoptotic signaling pathwaydefinition[GO:1990117]  
1
  • BHF-UCL
Blood vessel remodelingdefinition[GO:0001974] silver  
1
  • Ortholog Compara
Cellular response to UVdefinition[GO:0034644] silver  
1
  • Ortholog Compara
Cerebral cortex developmentdefinition[GO:0021987] silver  
1
  • Ortholog Compara
Development of secondary sexual characteristicsdefinition[GO:0045136] silver  
1
  • Ortholog Compara
Ectopic germ cell programmed cell deathdefinition[GO:0035234] silver  
1
  • Ortholog Compara
Endoplasmic reticulum calcium ion homeostasisdefinition[GO:0032469]  
1
  • UniProtKB
Establishment or maintenance of transmembrane electrochemical gradientdefinition[GO:0010248]  
1
  • HGNC
Extrinsic apoptotic signaling pathwaydefinition[GO:0097191]  
1
  • BHF-UCL
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192]  
1
  • RefGenome
Extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:0008625]  
1
  • BHF-UCL
Fertilizationdefinition[GO:0009566] silver  
1
  • Ortholog Compara
Germ cell developmentdefinition[GO:0007281] silver  
1
  • Ortholog Compara
Glycosphingolipid metabolic processdefinition[GO:0006687] silver  
1
  • Ortholog Compara
Homeostasis of number of cells within a tissuedefinition[GO:0048873] silver  
1
  • Ortholog Compara
Hypothalamus developmentdefinition[GO:0021854] silver  
1
  • Ortholog Compara
Intrinsic apoptotic signaling pathwaydefinition[GO:0097193]  
2
  • HGNC
  • BHF-UCL
Intrinsic apoptotic signaling pathway by p53 class mediatordefinition[GO:0072332] silver  
1
  • Ortholog Compara
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630]  
1
  • RefGenome
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:0070059]  
2
  • ParkinsonsUK-UCL
  • UniProtKB
Kidney developmentdefinition[GO:0001822] silver  
1
  • Ortholog Compara
Mitochondrial fragmentation involved in apoptotic processdefinition[GO:0043653]  
1
  • HGNC
Mitochondrial fusiondefinition[GO:0008053]  
1
  • HGNC
Mitochondrion morphogenesisdefinition[GO:0070584] silver  
1
  • Ortholog Compara
Myeloid cell homeostasisdefinition[GO:0002262] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic signaling pathwaydefinition[GO:2001234] silver  
1
  • Ortholog Compara
Negative regulation of endoplasmic reticulum calcium ion concentrationdefinition[GO:0032471] silver  
1
  • Ortholog Compara
Negative regulation of fibroblast proliferationdefinition[GO:0048147] silver  
1
  • Ortholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Negative regulation of peptidyl-serine phosphorylationdefinition[GO:0033137] silver  
1
  • Ortholog Compara
Negative regulation of protein bindingdefinition[GO:0032091]  
1
  • UniProtKB
Neuron apoptotic processdefinition[GO:0051402] silver  
1
  • Ortholog Compara
Neuron migrationdefinition[GO:0001764] silver  
1
  • Ortholog Compara
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
1
  • Ortholog Compara
Ovarian follicle developmentdefinition[GO:0001541] silver  
1
  • Ortholog Compara
Positive regulation of apoptotic DNA fragmentationdefinition[GO:1902512]  
1
  • BHF-UCL
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • UniProtKB
Positive regulation of apoptotic process involved in mammary gland involutiondefinition[GO:0060058] silver  
1
  • Ortholog Compara
Positive regulation of B cell apoptotic processdefinition[GO:0002904] silver  
1
  • Ortholog Compara
Positive regulation of developmental pigmentationdefinition[GO:0048087] silver  
1
  • Ortholog Compara
Positive regulation of endoplasmic reticulum unfolded protein responsedefinition[GO:1900103]  
1
  • UniProtKB
Positive regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001241] silver  
1
  • Ortholog Compara
Positive regulation of intrinsic apoptotic signaling pathwaydefinition[GO:2001244]  
2
  • UniProtKB
Positive regulation of IRE1-mediated unfolded protein responsedefinition[GO:1903896]  
1
  • ParkinsonsUK-UCL
Positive regulation of neuron apoptotic processdefinition[GO:0043525]  
1
  • HGNC
Positive regulation of protein oligomerizationdefinition[GO:0032461]  
1
  • UniProtKB
Positive regulation of release of cytochrome c from mitochondriadefinition[GO:0090200]  
1
  • UniProtKB
Positive regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051281] silver  
1
  • Ortholog Compara
Post-embryonic camera-type eye morphogenesisdefinition[GO:0048597] silver  
1
  • Ortholog Compara
Protein homooligomerizationdefinition[GO:0051260]  
2
  • UniProtKB
  • HGNC
Protein insertion into mitochondrial membrane involved in apoptotic signaling pathwaydefinition[GO:0001844] silver  
1
  • Ortholog Compara
Protein oligomerizationdefinition[GO:0051259]  
1
  • UniProtKB
Regulation of cell cycledefinition[GO:0051726] silver  
1
  • Ortholog Compara
Regulation of mammary gland epithelial cell proliferationdefinition[GO:0033599] silver  
1
  • Ortholog Compara
Regulation of mitochondrial membrane permeability involved in programmed necrotic cell deathdefinition[GO:1902445] silver  
1
  • Ortholog Compara
Regulation of mitochondrial membrane potentialdefinition[GO:0051881]  
1
  • HGNC
Regulation of nitrogen utilizationdefinition[GO:0006808] silver  
1
  • Ortholog Compara
Regulation of protein heterodimerization activitydefinition[GO:0043497]  
1
  • HGNC
Regulation of protein homodimerization activitydefinition[GO:0043496]  
1
  • HGNC
Release of cytochrome c from mitochondriadefinition[GO:0001836]  
3
  • HGNC
  • BHF-UCL
Release of matrix enzymes from mitochondriadefinition[GO:0032976]  
1
  • HGNC
Response to axon injurydefinition[GO:0048678] silver  
1
  • Ortholog Compara
Response to gamma radiationdefinition[GO:0010332] silver  
1
  • Ortholog Compara
Response to salt stressdefinition[GO:0009651] silver  
1
  • Ortholog Compara
Response to toxic substancedefinition[GO:0009636]  
1
  • HGNC
Retina development in camera-type eyedefinition[GO:0060041] silver  
1
  • Ortholog Compara
Retinal cell apoptotic processdefinition[GO:1990009]  
1
  • HGNC
Retinal cell programmed cell deathdefinition[GO:0046666] silver  
1
  • Ortholog Compara
Sertoli cell proliferationdefinition[GO:0060011] silver  
1
  • Ortholog Compara
Spermatid differentiationdefinition[GO:0048515] silver  
1
  • Ortholog Compara
T cell homeostatic proliferationdefinition[GO:0001777] silver  
1
  • Ortholog Compara
Thymocyte apoptotic processdefinition[GO:0070242] silver  
1
  • Ortholog Compara
Transformed cell apoptotic processdefinition[GO:0006927]  
1
  • HGNC
Vagina developmentdefinition[GO:0060068] silver  
1
  • Ortholog Compara
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amyotrophic lateral sclerosis (ALS)  hsa05014+581  
Apoptosis  hsa04210+581  
Colorectal cancer  hsa05210+581  
HTLV-I infection  hsa05166+581  
Huntington's disease  hsa05016+581  
Neurotrophin signaling pathway  hsa04722+581  
p53 signaling pathway  hsa04115+581  
Pathways in cancer  hsa05200+581  
Prion diseases  hsa05020+581  
Protein processing in endoplasmic reticulum  hsa04141+581  
Tuberculosis  hsa05152+581  
According to Reactome, this protein belongs to the following pathway:
Activation, translocation and oligomerization of BAX  REACT_584  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Bcl-2-associated_X_protein
GenomeRNAi: 581
PRO: PR:Q07812