BCL2L1 - Bcl-2-like protein 1 - human protein (Function)
 
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BCL2L1 »  Bcl-2-like protein 1  (Bcl2-L-1)
 
Protein also known as:  Apoptosis regulator Bcl-X.
Gene name:  BCL2L1
Family name: Bcl-2
Entry whose protein(s) existence is based on evidence at protein level
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1 473 3
GENE REF ISO

Function

 show evidences
Overview 
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.  
1
  • UniProtKB
Isoform  Bcl-X(L)   Also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles.  
1
  • UniProtKB
Isoform  Bcl-X(S)   Promotes apoptosis.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the bcl-2 (bcl-2) family  1.A.21.1.1  
GO molecular function 
BH3 domain bindingdefinition[GO:0051434]  
2
  • UniProtKB
Identical protein bindingdefinition[GO:0042802]  
2
  • IntAct
Protein bindingdefinition[GO:0005515]  
52
  • IntAct
  • UniProtKB
  • HGNC
  • ParkinsonsUK-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • RefGenome
Protein homodimerization activitydefinition[GO:0042803]  
1
  • RefGenome
Protein kinase bindingdefinition[GO:0019901]  
1
  • UniProtKB
GO biological process 
Apoptotic mitochondrial changesdefinition[GO:0008637]  
1
  • PINC
Apoptotic process in bone marrowdefinition[GO:0071839] silver  
1
  • Ortholog Compara
Cell proliferationdefinition[GO:0008283] silver  
1
  • Ortholog Compara
Cellular process regulating host cell cycle in response to virusdefinition[GO:0060154] silver  
1
  • Ortholog Compara
Cellular response to alkaloiddefinition[GO:0071312] silver  
1
  • Ortholog Compara
Cellular response to amino acid stimulusdefinition[GO:0071230] silver  
1
  • Ortholog Compara
Cellular response to gamma radiationdefinition[GO:0071480] silver  
1
  • Ortholog Compara
Cytokinesisdefinition[GO:0000910]  
1
  • UniProtKB
Endocytosisdefinition[GO:0006897]  
1
  • UniProtKB KW
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192]  
1
  • RefGenome
Fertilizationdefinition[GO:0009566] silver  
1
  • Ortholog Compara
Germ cell developmentdefinition[GO:0007281] silver  
1
  • Ortholog Compara
Growthdefinition[GO:0040007] silver  
1
  • Ortholog Compara
Hepatocyte apoptotic processdefinition[GO:0097284] silver  
1
  • Ortholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630] silver  
1
  • Ortholog Compara
Male gonad developmentdefinition[GO:0008584] silver  
1
  • Ortholog Compara
Mitochondrion morphogenesisdefinition[GO:0070584] silver  
1
  • Ortholog Compara
Mitotic cell cycle checkpointdefinition[GO:0007093]  
1
  • UniProtKB
Isoform  Bcl-X(L)   Negative regulation of anoikisdefinition[GO:2000811]  
1
  • UniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
4
  • UniProtKB
  • MGI
Isoform  Bcl-X(L)   Negative regulation of autophagydefinition[GO:0010507]  
1
  • UniProtKB
Negative regulation of establishment of protein localization to plasma membranedefinition[GO:0090005]  
1
  • BHF-UCL
Negative regulation of execution phase of apoptosisdefinition[GO:1900118]  
1
  • UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240]  
1
  • BHF-UCL
Negative regulation of intrinsic apoptotic signaling pathwaydefinition[GO:2001243]  
2
  • UniProtKB
  • BHF-UCL
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:1902230]  
1
  • BHF-UCL
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Negative regulation of release of cytochrome c from mitochondriadefinition[GO:0090201]  
2
  • BHF-UCL
  • UniProtKB
Neuron apoptotic processdefinition[GO:0051402] silver  
1
  • Ortholog Compara
Ovarian follicle developmentdefinition[GO:0001541] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Regulation of mitochondrial membrane permeabilitydefinition[GO:0046902]  
1
  • HGNC
Regulation of mitochondrial membrane potentialdefinition[GO:0051881]  
1
  • HGNC
Release of cytochrome c from mitochondriadefinition[GO:0001836]  
1
  • HGNC
Response to cycloheximidedefinition[GO:0046898] silver  
1
  • Ortholog Compara
Response to cytokinedefinition[GO:0034097]  
1
  • MGI
Spermatogenesisdefinition[GO:0007283] silver  
1
  • Ortholog Compara
Suppression by virus of host apoptotic processdefinition[GO:0019050]  
1
  • MGI
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amyotrophic lateral sclerosis (ALS)  hsa05014+598  
Apoptosis  hsa04210+598  
Chronic myeloid leukemia  hsa05220+598  
HTLV-I infection  hsa05166+598  
Jak-STAT signaling pathway  hsa04630+598  
Pancreatic cancer  hsa05212+598  
Pathways in cancer  hsa05200+598  
Small cell lung cancer  hsa05222+598  
Toxoplasmosis  hsa05145+598  
According to Reactome, this protein belongs to the following pathways:
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members  REACT_330  
The NLRP1 inflammasome  REACT_75927  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Endocytosis  definition   [KW-0254]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BCL2-like_1_(gene)
GenomeRNAi: 598
PRO: PR:Q07817