BCL2L1 - Bcl-2-like protein 1 - human protein (Function)
 
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BCL2L1 »  Bcl-2-like protein 1  (Bcl2-L-1)
 
Protein also known as:  Apoptosis regulator Bcl-X.
Gene name:  BCL2L1
Family name: Bcl-2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 421 3
GENE REF ISO

Function

 show evidences
Overview 
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.  
3
  • CuratedUniProtKB
Isoform  Bcl-X(L)   Also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles.  
3
  • CuratedUniProtKB
Isoform  Bcl-X(S)   Promotes apoptosis.  
3
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the bcl-2 (bcl-2) family  1.A.21.1.1  
GO molecular function 
Isoform  Bcl-X(L)   BH3 domain bindingdefinition[GO:0051434]  
1
  • IPIUniProtKB
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Protein bindingdefinition[GO:0005515]  
48
  • IPIIntAct
  • IPIUniProtKB
  • IPIHGNC
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IBARefGenome
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IBARefGenome
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
GO biological process 
Apoptotic mitochondrial changesdefinition[GO:0008637]  
1
  • TASPINC
Apoptotic process in bone marrowdefinition[GO:0071839] silver  
  • IEAOrtholog Compara
Cell proliferationdefinition[GO:0008283] silver  
  • IEAOrtholog Compara
Cellular process regulating host cell cycle in response to virusdefinition[GO:0060154] silver  
  • IEAOrtholog Compara
Cellular response to alkaloiddefinition[GO:0071312] silver  
  • IEAOrtholog Compara
Cellular response to amino acid stimulusdefinition[GO:0071230] silver  
  • IEAOrtholog Compara
Cellular response to gamma radiationdefinition[GO:0071480] silver  
  • IEAOrtholog Compara
Cytokinesisdefinition[GO:0000910]  
1
  • IMPUniProtKB
Endocytosisdefinition[GO:0006897]  
  • IEAUniProtKB KW
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
  • IBARefGenome
Fertilizationdefinition[GO:0009566] silver  
  • IEAOrtholog Compara
Germ cell developmentdefinition[GO:0007281] silver  
  • IEAOrtholog Compara
Growthdefinition[GO:0040007] silver  
  • IEAOrtholog Compara
Hepatocyte apoptotic processdefinition[GO:0097284] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630] silver  
  • IEAOrtholog Compara
Male gonad developmentdefinition[GO:0008584] silver  
  • IEAOrtholog Compara
Mitotic cell cycle checkpointdefinition[GO:0007093]  
1
  • IMPUniProtKB
Isoform  Bcl-X(L)   Negative regulation of anoikisdefinition[GO:2000811]  
1
  • IMPUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
4
  • IDAUniProtKB
  • IDAMGI
Isoform  Bcl-X(L)   Negative regulation of autophagydefinition[GO:0010507]  
1
  • TASUniProtKB
Negative regulation of establishment of protein localization to plasma membranedefinition[GO:0090005]  
1
  • IDABHF-UCL
Negative regulation of execution phase of apoptosisdefinition[GO:1900118]  
1
  • IDAUniProtKB
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240]  
1
  • TASBHF-UCL
Negative regulation of intrinsic apoptotic signaling pathwaydefinition[GO:2001243]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:1902230]  
1
  • IDABHF-UCL
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Negative regulation of release of cytochrome c from mitochondriadefinition[GO:0090201]  
2
  • ICBHF-UCL
  • IDAUniProtKB
Neuron apoptotic processdefinition[GO:0051402] silver  
  • IEAOrtholog Compara
Ovarian follicle developmentdefinition[GO:0001541] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Regulation of mitochondrial membrane permeabilitydefinition[GO:0046902]  
1
  • IDAHGNC
Regulation of mitochondrial membrane potentialdefinition[GO:0051881]  
1
  • IDAHGNC
Release of cytochrome c from mitochondriadefinition[GO:0001836]  
1
  • IDAHGNC
Response to cycloheximidedefinition[GO:0046898] silver  
  • IEAOrtholog Compara
Response to cytokinedefinition[GO:0034097]  
1
  • IDAMGI
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Suppression by virus of host apoptotic processdefinition[GO:0019050]  
1
  • IDAMGI
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amyotrophic lateral sclerosis (ALS)  hsa05014+598  
Apoptosis  hsa04210+598  
Chronic myeloid leukemia  hsa05220+598  
HTLV-I infection  hsa05166+598  
Jak-STAT signaling pathway  hsa04630+598  
Pancreatic cancer  hsa05212+598  
Pathways in cancer  hsa05200+598  
Small cell lung cancer  hsa05222+598  
Toxoplasmosis  hsa05145+598  
According to Reactome, this protein belongs to the following pathways:
Apoptosis  REACT_578  
Immune System  REACT_6900  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Endocytosis  definition   [KW-0254]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BCL2-like_1_(gene)
GenomeRNAi: 598
PRO: PR:Q07817