POLE - DNA polymerase epsilon catalytic subunit A - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
POLE »  DNA polymerase epsilon catalytic subunit A   [ EC 2.7.7.7 ]
 
Protein also known as:  DNA polymerase II subunit A.
Gene name:  POLE
Family name: DNA polymerase type-B
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 61 1
GENE REF ISO

Function

 show evidences
Overview 
Participates in DNA repair and in chromosomal DNA replication.  
  • CuratedUniProtKB
GO molecular function 
4 iron, 4 sulfur cluster bindingdefinition[GO:0051539]  
  • IEAUniProtKB KW
Chromatin bindingdefinition[GO:0003682]  
1
  • IDAUniProtKB
DNA bindingdefinition[GO:0003677]  
1
  • IDAUniProtKB
DNA-directed DNA polymerase activitydefinition[GO:0003887]  
1
  • IMPUniProtKB
Nucleotide bindingdefinition[GO:0000166] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Base-excision repair, gap-fillingdefinition[GO:0006287]  
1
  • IDAUniProtKB
DNA replicationdefinition[GO:0006260]  
1
  • IMPUniProtKB
DNA synthesis involved in DNA repairdefinition[GO:0000731]  
1
  • IMPUniProtKB
G1/S transition of mitotic cell cycledefinition[GO:0000082]  
1
  • IMPUniProtKB
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Nucleotide-excision repair, DNA gap fillingdefinition[GO:0006297]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.7.7: Deoxynucleoside triphosphate + DNA(n) diphosphate + DNA(n+1).  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 4Fe-4S cluster (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Base excision repair  hsa03410+5426  
DNA replication  hsa03030+5426  
HTLV-I infection  hsa05166+5426  
Metabolic pathways  hsa01100+5426  
Nucleotide excision repair  hsa03420+5426  
Purine metabolism  hsa00230+5426  
Pyrimidine metabolism  hsa00240+5426  
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
DNA Repair  REACT_216  
DNA Replication  REACT_383  
Mitotic M-M/G1 phases  REACT_21300  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
DNA replication  definition   [KW-0235]
Molecular function 
DNA-directed DNA polymerase  definition   [KW-0239]
Nucleotidyltransferase  definition   [KW-0548]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: POLE_(enzyme)
GenomeRNAi: 5426
PRO: PR:Q07864