PPARA - Peroxisome proliferator-activated receptor alpha - human protein (Function)
 
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References

 
PPARA »  Peroxisome proliferator-activated receptor alpha  (PPAR-alpha)
 
Protein also known as:  Nuclear receptor subfamily 1 group C member 1.
Gene name:  PPARA
Family name: Nuclear hormone receptor » NR1
Entry whose protein(s) existence is based on evidence at protein level
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1 83 2
GENE REF ISO

Function

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Overview 
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.  
5
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • PINC
Drug bindingdefinition[GO:0008144]  
2
  • UniProtKB
  • BHF-UCL
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879]  
2
  • BHF-UCL
  • UniProtKB
Lipid bindingdefinition[GO:0008289]  
1
  • UniProtKB
MDM2/MDM4 family protein bindingdefinition[GO:0097371] silver  
1
  • Ortholog Compara
NFAT protein bindingdefinition[GO:0051525] silver  
1
  • Ortholog Compara
Phosphatase bindingdefinition[GO:0019902] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
Protein domain specific bindingdefinition[GO:0019904] silver  
1
  • Ortholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • NTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001078]  
1
  • NTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • NTNU_SB
RNA polymerase II repressing transcription factor bindingdefinition[GO:0001103]  
1
  • BHF-UCL
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001190] silver  
1
  • Ortholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • Ortholog Curator
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • BHF-UCL
  • Ortholog Curator
Steroid hormone receptor activitydefinition[GO:0003707]  
1
  • BHF-UCL
Ubiquitin conjugating enzyme bindingdefinition[GO:0031624]  
1
  • BHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Behavioral response to nicotinedefinition[GO:0035095] silver  
1
  • Ortholog Compara
Circadian regulation of gene expressiondefinition[GO:0032922]  
1
  • Ortholog Curator
Enamel mineralizationdefinition[GO:0070166] silver  
1
  • Ortholog Compara
Epidermis developmentdefinition[GO:0008544] silver  
1
  • Ortholog Compara
Fatty acid metabolic processdefinition[GO:0006631] silver  
1
  • Ortholog Compara
Fatty acid transportdefinition[GO:0015908]  
1
  • UniProtKB
Heart developmentdefinition[GO:0007507] silver  
1
  • Ortholog Compara
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
4
  • GOC
  • Ortholog Compara
  • InterPro 2 GO
Lipid metabolic processdefinition[GO:0006629]  
2
  • PINC
Lipoprotein metabolic processdefinition[GO:0042157] silver  
1
  • Ortholog Compara
Negative regulation of appetitedefinition[GO:0032099]  
1
  • Ortholog Curator
Negative regulation of blood pressuredefinition[GO:0045776] silver  
1
  • Ortholog Compara
Negative regulation of cholesterol storagedefinition[GO:0010887]  
1
  • BHF-UCL
Negative regulation of glycolytic processdefinition[GO:0045820]  
1
  • BHF-UCL
Negative regulation of macrophage derived foam cell differentiationdefinition[GO:0010745]  
2
  • BHF-UCL
Negative regulation of neuron deathdefinition[GO:1901215] silver  
1
  • Ortholog Compara
Negative regulation of protein bindingdefinition[GO:0032091] silver  
1
  • Ortholog Compara
Negative regulation of receptor biosynthetic processdefinition[GO:0010871]  
1
  • BHF-UCL
Negative regulation of sequestering of triglyceridedefinition[GO:0010891]  
1
  • BHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
2
  • BHF-UCL
  • NTNU_SB
Negative regulation of transcription regulatory region DNA bindingdefinition[GO:2000678] silver  
1
  • Ortholog Compara
Positive regulation of fatty acid beta-oxidationdefinition[GO:0032000]  
1
  • UniProtKB
Positive regulation of fatty acid oxidationdefinition[GO:0046321]  
1
  • Ortholog Curator
Positive regulation of gluconeogenesisdefinition[GO:0045722] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
3
  • BHF-UCL
  • NTNU_SB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0072366]  
1
  • BHF-UCL
Regulation of circadian rhythmdefinition[GO:0042752]  
1
  • Ortholog Curator
Regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0072363]  
1
  • BHF-UCL
Regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0072369]  
1
  • BHF-UCL
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to insulindefinition[GO:0032868] silver  
1
  • Ortholog Compara
Steroid hormone mediated signaling pathwaydefinition[GO:0043401] silver  
1
  • InterPro 2 GO
Wound healingdefinition[GO:0042060] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+5465  
Hepatitis C  hsa05160+5465  
PPAR signaling pathway  hsa03320+5465  
According to Reactome, this protein belongs to the following pathways:
Activation of gene expression by SREBF (SREBP)  REACT_147904  
BMAL1:CLOCK,NPAS2 activates circadian gene expression  REACT_111118  
Circadian Clock  REACT_24941  
Nuclear Receptor transcription pathway  REACT_15525  
Orphan transporters  REACT_267716  
PPARA activates gene expression  REACT_116145  
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)  REACT_19241  
REV-ERBA represses gene expression  REACT_118789  
RORA activates circadian gene expression  REACT_118659  
Transcriptional activation of mitochondrial biogenesis  REACT_200608  
Transcriptional regulation of white adipocyte differentiation  REACT_27161  
YAP1- and WWTR1 (TAZ)-stimulated gene expression  REACT_118713  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Peroxisome_proliferator-activated_receptor_alpha
GenomeRNAi: 5465
PRO: PR:Q07869
Chemistry
GuidetoPHARMACOLOGY: 593