PPARA - Peroxisome proliferator-activated receptor alpha - human protein (Function)
 
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Protein
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References

 
PPARA »  Peroxisome proliferator-activated receptor alpha  (PPAR-alpha)
 
Protein also known as:  Nuclear receptor subfamily 1 group C member 1.
Gene name:  PPARA
Family name: Nuclear hormone receptor » NR1
Entry whose protein(s) existence is based on evidence at protein level
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1 78 2
GENE REF ISO

Function

 show evidences
Overview 
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.  
4
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • TASPINC
Drug bindingdefinition[GO:0008144]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Lipid bindingdefinition[GO:0008289]  
1
  • IDAUniProtKB
MDM2/MDM4 family protein bindingdefinition[GO:0097371] silver  
  • IEAOrtholog Compara
NFAT protein bindingdefinition[GO:0051525] silver  
  • IEAOrtholog Compara
Phosphatase bindingdefinition[GO:0019902] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
RNA polymerase II repressing transcription factor bindingdefinition[GO:0001103]  
1
  • IPIBHF-UCL
Sequence-specific DNA bindingdefinition[GO:0043565]  
  • ISSOrtholog Curator
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Steroid hormone receptor activitydefinition[GO:0003707]  
1
  • IDABHF-UCL
Ubiquitin conjugating enzyme bindingdefinition[GO:0031624]  
1
  • IPIBHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Behavioral response to nicotinedefinition[GO:0035095] silver  
  • IEAOrtholog Compara
Circadian regulation of gene expressiondefinition[GO:0032922]  
  • ISSOrtholog Curator
Enamel mineralizationdefinition[GO:0070166] silver  
  • IEAOrtholog Compara
Epidermis developmentdefinition[GO:0008544] silver  
  • IEAOrtholog Compara
Fatty acid metabolic processdefinition[GO:0006631] silver  
  • IEAOrtholog Compara
Fatty acid transportdefinition[GO:0015908]  
1
  • TASUniProtKB
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
2
  • IDAGOC
Lipid metabolic processdefinition[GO:0006629]  
2
  • TASPINC
Lipoprotein metabolic processdefinition[GO:0042157] silver  
  • IEAOrtholog Compara
Negative regulation of appetitedefinition[GO:0032099]  
  • ISSOrtholog Curator
Negative regulation of blood pressuredefinition[GO:0045776] silver  
  • IEAOrtholog Compara
Negative regulation of cholesterol storagedefinition[GO:0010887]  
1
  • IDABHF-UCL
Negative regulation of glycolytic processdefinition[GO:0045820]  
1
  • ICBHF-UCL
Negative regulation of macrophage derived foam cell differentiationdefinition[GO:0010745]  
2
  • IDABHF-UCL
Negative regulation of neuron deathdefinition[GO:1901215] silver  
  • IEAOrtholog Compara
Negative regulation of protein bindingdefinition[GO:0032091] silver  
  • IEAOrtholog Compara
Negative regulation of receptor biosynthetic processdefinition[GO:0010871]  
1
  • IDABHF-UCL
Negative regulation of sequestering of triglyceridedefinition[GO:0010891]  
1
  • IDABHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDABHF-UCL
Negative regulation of transcription regulatory region DNA bindingdefinition[GO:2000678] silver  
  • IEAOrtholog Compara
Positive regulation of fatty acid beta-oxidationdefinition[GO:0032000]  
1
  • TASUniProtKB
Positive regulation of fatty acid oxidationdefinition[GO:0046321]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0072366]  
1
  • IDABHF-UCL
Regulation of circadian rhythmdefinition[GO:0042752]  
  • ISSOrtholog Curator
Regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0072363]  
1
  • IDABHF-UCL
Regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0072369]  
1
  • IDABHF-UCL
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Wound healingdefinition[GO:0042060] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+5465  
Hepatitis C  hsa05160+5465  
PPAR signaling pathway  hsa03320+5465  
According to Reactome, this protein belongs to the following pathways:
Circadian Clock  REACT_24941  
Gene Expression  REACT_71  
Metabolism  REACT_111217  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Peroxisome_proliferator-activated_receptor_alpha
GenomeRNAi: 5465
PRO: PR:Q07869
Chemistry
GuidetoPHARMACOLOGY: 593