LRP1 - Prolow-density lipoprotein receptor-related protein 1 - human protein (Function)
 
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LRP1 »  Prolow-density lipoprotein receptor-related protein 1  (LRP-1)
 
Protein also known as:  Alpha-2-macroglobulin receptor (A2MR); CD antigen CD91. Cleaved into:  Low-density lipoprotein receptor-related protein 1 515 kDa subunit; Low-density lipoprotein receptor-related protein 1 85 kDa subunit; Low-density lipoprotein receptor-related protein 1 intracellular domain.
Gene name:  LRP1
Family name: LDLR
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 258 1
GENE REF ISO

Function

 show evidences
Overview 
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.  
5
  • CuratedUniProtKB
Functions as a receptor for Pseudomonas aeruginosa exotoxin A.  
5
  • CuratedUniProtKB
GO molecular function 
Apolipoprotein bindingdefinition[GO:0034185]  
2
  • IPIBHF-UCL
  • IDAUniProtKB
Calcium ion bindingdefinition[GO:0005509]  
  • ISSOrtholog Curator
Lipoprotein particle receptor bindingdefinition[GO:0070325]  
1
  • ICBHF-UCL
Lipoprotein transporter activitydefinition[GO:0042954]  
1
  • NASUniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protease bindingdefinition[GO:0002020] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIBHF-UCL
Protein complex bindingdefinition[GO:0032403]  
1
  • IDABHF-UCL
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Aorta morphogenesisdefinition[GO:0035909]  
  • ISSOrtholog Curator
Apoptotic cell clearancedefinition[GO:0043277]  
  • ISSOrtholog Curator
Beta-amyloid clearancedefinition[GO:0097242]  
1
  • TASBHF-UCL
Cell proliferationdefinition[GO:0008283] silver  
  • IEAOrtholog Compara
Cholesterol metabolic processdefinition[GO:0008203] silver  
  • IEAOrtholog Compara
Lipoprotein metabolic processdefinition[GO:0042157] silver  
  • IEAOrtholog Compara
Lipoprotein transportdefinition[GO:0042953]  
1
  • NASUniProtKB
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Negative regulation of platelet-derived growth factor receptor-beta signaling pathwaydefinition[GO:2000587]  
  • ISSOrtholog Curator
Negative regulation of smooth muscle cell migrationdefinition[GO:0014912]  
  • ISSOrtholog Curator
Negative regulation of Wnt signaling pathwaydefinition[GO:0030178]  
  • ISSOrtholog Curator
Positive regulation of cholesterol effluxdefinition[GO:0010875]  
  • ISSOrtholog Curator
Positive regulation of lipid transportdefinition[GO:0032370]  
  • ISSOrtholog Curator
Positive regulation of protein transportdefinition[GO:0051222] silver  
  • IEAOrtholog Compara
Protein kinase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007205] silver  
  • IEAOrtholog Compara
Receptor-mediated endocytosisdefinition[GO:0006898] silver  
  • IEAOrtholog Compara
Regulation of actin cytoskeleton organizationdefinition[GO:0032956]  
  • ISSOrtholog Curator
Regulation of cholesterol transportdefinition[GO:0032374]  
  • ISSOrtholog Curator
Regulation of phospholipase A2 activitydefinition[GO:0032429]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+4035  
Malaria  hsa05144+4035  
According to Reactome, this protein belongs to the following pathways:
Retinoid metabolism and transport  REACT_24968  
Scavenging of heme from plasma  REACT_160163  
 

Keywords

Biological process 
Endocytosis  definition   [KW-0254]
Molecular function 
Developmental protein  definition   [KW-0217]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LRP1
GenomeRNAi: 4035
PRO: PR:Q07954