LRP1 - Prolow-density lipoprotein receptor-related protein 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
LRP1 »  Prolow-density lipoprotein receptor-related protein 1  (LRP-1)
 
Protein also known as:  Alpha-2-macroglobulin receptor (A2MR); CD antigen CD91. Cleaved into:  Low-density lipoprotein receptor-related protein 1 515 kDa subunit; Low-density lipoprotein receptor-related protein 1 85 kDa subunit; Low-density lipoprotein receptor-related protein 1 intracellular domain.
Gene name:  LRP1
Family name: LDLR
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 276 2
GENE REF ISO

Function

 show evidences
Overview 
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.  
1
  • UniProtKB
Functions as a receptor for Pseudomonas aeruginosa exotoxin A.  
1
  • UniProtKB
GO molecular function 
Apolipoprotein bindingdefinition[GO:0034185]  
2
  • BHF-UCL
  • UniProtKB
Calcium ion bindingdefinition[GO:0005509]  
1
  • Ortholog Curator
Lipoprotein particle receptor bindingdefinition[GO:0070325]  
1
  • BHF-UCL
Lipoprotein transporter activitydefinition[GO:0042954]  
1
  • UniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protease bindingdefinition[GO:0002020] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • BHF-UCL
Protein complex bindingdefinition[GO:0032403]  
1
  • BHF-UCL
Receptor activitydefinition[GO:0004872]  
1
  • PINC
GO biological process 
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Aorta morphogenesisdefinition[GO:0035909]  
1
  • Ortholog Curator
Apoptotic cell clearancedefinition[GO:0043277]  
1
  • Ortholog Curator
Beta-amyloid clearancedefinition[GO:0097242]  
1
  • BHF-UCL
Cell proliferationdefinition[GO:0008283] silver  
1
  • Ortholog Compara
Cholesterol metabolic processdefinition[GO:0008203] silver  
1
  • Ortholog Compara
Lipoprotein metabolic processdefinition[GO:0042157] silver  
1
  • Ortholog Compara
Lipoprotein transportdefinition[GO:0042953]  
1
  • UniProtKB
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Negative regulation of platelet-derived growth factor receptor-beta signaling pathwaydefinition[GO:2000587]  
1
  • Ortholog Curator
Negative regulation of smooth muscle cell migrationdefinition[GO:0014912]  
1
  • Ortholog Curator
Negative regulation of Wnt signaling pathwaydefinition[GO:0030178]  
1
  • Ortholog Curator
Positive regulation of cholesterol effluxdefinition[GO:0010875]  
1
  • Ortholog Curator
Positive regulation of lipid transportdefinition[GO:0032370]  
1
  • Ortholog Curator
Positive regulation of protein transportdefinition[GO:0051222] silver  
1
  • Ortholog Compara
Protein kinase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007205] silver  
1
  • Ortholog Compara
Regulation of actin cytoskeleton organizationdefinition[GO:0032956]  
1
  • Ortholog Curator
Regulation of cholesterol transportdefinition[GO:0032374]  
1
  • Ortholog Curator
Regulation of phospholipase A2 activitydefinition[GO:0032429]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+4035  
Malaria  hsa05144+4035  
According to Reactome, this protein belongs to the following pathways:
Retinoid metabolism and transport  REACT_24968  
Scavenging of heme from plasma  REACT_160163  
 

Keywords

Biological process 
Endocytosis  definition   [KW-0254]
Molecular function 
Developmental protein  definition   [KW-0217]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LRP1
GenomeRNAi: 4035
PRO: PR:Q07954