CYP24A1 - 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial - human protein (Function)
 
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CYP24A1 »  1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial   [ EC 1.14.13.126 ]  (24-OHase)
 
Protein also known as:  Cytochrome P450-CC24.
Gene name:  CYP24A1
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 93 3
GENE REF ISO

Function

 show evidences
Overview 
Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.  
  • CuratedUniProtKB
GO molecular function 
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activitydefinition[GO:0030342]  
1
  • IDAUniProtKB
25-hydroxycholecalciferol-24-hydroxylase activitydefinition[GO:0008403] silver  
  • IEAOrtholog Compara
Heme bindingdefinition[GO:0020037]  
1
  • TASUniProtKB
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Oxidoreductase activitydefinition[GO:0016491]  
1
  • NASUniProtKB
GO biological process 
Osteoblast differentiationdefinition[GO:0001649]  
1
  • IEPBHF-UCL
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDAUniProtKB
Response to vitamin Ddefinition[GO:0033280]  
1
  • IDABHF-UCL
Vitamin D catabolic processdefinition[GO:0042369]  
1
  • NASBHF-UCL
Vitamin D receptor signaling pathwaydefinition[GO:0070561]  
1
  • NASBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
Calcitriol + NADPH + O(2) calcitetrol + NADP(+) + H(2)O.  
  • CuratedUniProtKB
Calcidiol + NADPH + O(2) secalciferol + NADP(+) + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Heme group (By similarity).  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Steroid hormones  REACT_15493  
 
More information is available from:
 

Keywords

Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q07973
Other
GeneWiki: CYP24A1
GenomeRNAi: 1591
PRO: PR:Q07973