FOXM1 - Forkhead box protein M1 - human protein (Function)
 
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Protein
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References

 
FOXM1 »  Forkhead box protein M1
 
Protein also known as:  Hepatocyte nuclear factor 3 forkhead homolog 11 (HFH-11).
Gene name:  FOXM1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 148 3
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.  
3
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
2
  • TASUniProtKB
DNA binding, bendingdefinition[GO:0008301] silver  
  • IBARefGenome
Double-stranded DNA bindingdefinition[GO:0003690] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705] silver  
  • IBARefGenome
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
3
  • IDAUniProtKB
Transcription factor bindingdefinition[GO:0008134] silver  
  • IBARefGenome
Transcription regulatory region DNA bindingdefinition[GO:0044212] silver  
  • IEAOrtholog Compara
GO biological process 
Isoform  Iso 1   Cell cycledefinition[GO:0007049]  
1
  • TASUniProtKB
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatordefinition[GO:0006978]  
1
  • IMPUniProtKB
DNA repairdefinition[GO:0006281]  
  • IEAUniProtKB KW
Embryo developmentdefinition[GO:0009790] silver  
  • IBARefGenome
G2/M transition of mitotic cell cycledefinition[GO:0000086]  
1
  • IDAUniProtKB
Liver developmentdefinition[GO:0001889] silver  
  • IBARefGenome
Negative regulation of cell agingdefinition[GO:0090344]  
1
  • IMPUniProtKB
Negative regulation of stress-activated MAPK cascadedefinition[GO:0032873]  
1
  • IMPBHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IMPBHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IMPBHF-UCL
Pattern specification processdefinition[GO:0007389] silver  
  • IBARefGenome
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IMPBHF-UCL
Positive regulation of double-strand break repairdefinition[GO:2000781]  
1
  • IMPUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IMPBHF-UCL
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IMPBHF-UCL
  • IMPUniProtKB
Regulation of cell cycle arrestdefinition[GO:0071156]  
1
  • IMPBHF-UCL
Isoform  Iso 1   Regulation of cell growthdefinition[GO:0001558]  
1
  • TASUniProtKB
Isoform  Iso 4   Regulation of cell proliferationdefinition[GO:0042127]  
1
  • NASUniProtKB
Regulation of Ras protein signal transductiondefinition[GO:0046578]  
1
  • IMPBHF-UCL
Regulation of reactive oxygen species metabolic processdefinition[GO:2000377]  
1
  • IMPBHF-UCL
Regulation of RNA biosynthetic processdefinition[GO:2001141]  
3
  • IDAGOC
Regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051090] silver  
  • IBARefGenome
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
3
  • IDAGOC
Tissue developmentdefinition[GO:0009888] silver  
  • IBARefGenome
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • IDAUniProtKB
  • IBARefGenome
Vasculogenesisdefinition[GO:0001570] silver  
  • IBARefGenome
Pathways 
According to Reactome, this protein belongs to the following pathway:
Cell Cycle  REACT_115566  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FOXM1
GenomeRNAi: 2305
PRO: PR:Q08050