CACNB2 - Voltage-dependent L-type calcium channel subunit beta-2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CACNB2 »  Voltage-dependent L-type calcium channel subunit beta-2  (CAB2)
 
Protein also known as:  Calcium channel voltage-dependent subunit beta 2.
Gene name:  CACNB2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 42 10
GENE REF ISO

Function

 show evidences
Overview 
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ca(2+) channel auxiliary subunit types 1-4 (cca-) family  8.A.22.1.2  
GO molecular function 
Calcium channel activitydefinition[GO:0005262]  
1
  • NASUniProtKB
Contributes to high voltage-gated calcium channel activitydefinition[GO:0008331]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Voltage-gated calcium channel activitydefinition[GO:0005245]  
1
  • IDABHF-UCL
GO biological process 
Calcium ion importdefinition[GO:0070509]  
1
  • IDABHF-UCL
Neuromuscular junction developmentdefinition[GO:0007528]  
1
  • TASPINC
Positive regulation of calcium ion transportdefinition[GO:0051928]  
1
  • IDABHF-UCL
Synaptic transmissiondefinition[GO:0007268] silver  
  • IEAOrtholog Compara
Transportdefinition[GO:0006810]  
2
  • TASPINC
Visual perceptiondefinition[GO:0007601] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+783  
Cardiac muscle contraction  hsa04260+783  
Dilated cardiomyopathy  hsa05414+783  
Hypertrophic cardiomyopathy (HCM)  hsa05410+783  
MAPK signaling pathway  hsa04010+783  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Metabolism  REACT_111217  
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CACNB2
GenomeRNAi: 783
PRO: PR:Q08289