DDR1 - Epithelial discoidin domain-containing receptor 1 - human protein (Function)
 
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DDR1 »  Epithelial discoidin domain-containing receptor 1   [ EC 2.7.10.1 ]  (Epithelial discoidin domain receptor 1)
 
Protein also known as:  Discoidin receptor tyrosine kinase; CD antigen CD167a.
Gene name:  DDR1
Entry whose protein(s) existence is based on evidence at protein level
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1 81 5
GENE REF ISO

Function

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Overview 
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.  
8
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Collagen bindingdefinition[GO:0005518]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein tyrosine kinase collagen receptor activitydefinition[GO:0038062]  
2
  • IDAUniProtKB
Transmembrane receptor protein tyrosine kinase activitydefinition[GO:0004714]  
1
  • TASPINC
GO biological process 
Branching involved in mammary gland duct morphogenesisdefinition[GO:0060444] silver  
  • IEAOrtholog Compara
Cell adhesiondefinition[GO:0007155]  
1
  • TASPINC
Collagen-activated tyrosine kinase receptor signaling pathwaydefinition[GO:0038063]  
2
  • IDAUniProtKB
Ear developmentdefinition[GO:0043583] silver  
  • IEAOrtholog Compara
Embryo implantationdefinition[GO:0007566] silver  
  • IEAOrtholog Compara
Lactationdefinition[GO:0007595]  
  • IEAUniProtKB KW
Mammary gland alveolus developmentdefinition[GO:0060749] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Peptidyl-tyrosine autophosphorylationdefinition[GO:0038083]  
1
  • IDAUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAUniProtKB
Regulation of cell growthdefinition[GO:0001558] silver  
  • IEAOrtholog Compara
Regulation of cell-matrix adhesiondefinition[GO:0001952] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Extracellular matrix organization  REACT_118779  
 

Keywords

Biological process 
Lactation  definition   [KW-0421]
Pregnancy  definition   [KW-0635]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: DDR1
GenomeRNAi: 780
PRO: PR:Q08345
Chemistry
GuidetoPHARMACOLOGY: 1843