DDR1 - Epithelial discoidin domain-containing receptor 1 - human protein (Function)
 
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DDR1 »  Epithelial discoidin domain-containing receptor 1   [ EC 2.7.10.1 ]  (Epithelial discoidin domain receptor 1)
 
Protein also known as:  Discoidin receptor tyrosine kinase; CD antigen CD167a.
Gene name:  DDR1
Entry whose protein(s) existence is based on evidence at protein level
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1 118 5
GENE REF ISO

Function

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Overview 
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.  
10
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Collagen bindingdefinition[GO:0005518]  
2
  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
  • IntAct
Protein tyrosine kinase collagen receptor activitydefinition[GO:0038062]  
2
  • UniProtKB
Transmembrane receptor protein tyrosine kinase activitydefinition[GO:0004714]  
1
  • PINC
GO biological process 
Branching involved in mammary gland duct morphogenesisdefinition[GO:0060444] silver  
1
  • Ortholog Compara
Cell adhesiondefinition[GO:0007155]  
1
  • PINC
Collagen-activated tyrosine kinase receptor signaling pathwaydefinition[GO:0038063]  
3
  • UniProtKB
Ear developmentdefinition[GO:0043583] silver  
1
  • Ortholog Compara
Embryo implantationdefinition[GO:0007566] silver  
1
  • Ortholog Compara
Lactationdefinition[GO:0007595]  
1
  • UniProtKB KW
Mammary gland alveolus developmentdefinition[GO:0060749] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
1
  • Ortholog Compara
Peptidyl-tyrosine autophosphorylationdefinition[GO:0038083]  
1
  • UniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • UniProtKB
Regulation of cell growthdefinition[GO:0001558] silver  
1
  • Ortholog Compara
Regulation of cell-matrix adhesiondefinition[GO:0001952] silver  
1
  • Ortholog Compara
Regulation of extracellular matrix disassemblydefinition[GO:0010715]  
1
  • UniProtKB
Smooth muscle cell migrationdefinition[GO:0014909]  
1
  • UniProtKB
Smooth muscle cell-matrix adhesiondefinition[GO:0061302]  
1
  • UniProtKB
Wound healing, spreading of cellsdefinition[GO:0044319]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • PROSITE-ProRule
  • UniProtKB
It is regulated in the following manner
Inhibited by the multi-targeted cancer drugs imatinib and ponatinib.  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Non-integrin membrane-ECM interactions  REACT_163874  
Caution 
The mutant Gln-371 studied is still likely to be glycosylated at Asn-370, but study did not include mutagenesis of Asn-370.  
2
  • UniProtKB
 

Keywords

Biological process 
Lactation  definition   [KW-0421]
Pregnancy  definition   [KW-0635]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: DDR1
GenomeRNAi: 780
PRO: PR:Q08345
Chemistry
GuidetoPHARMACOLOGY: 1843