SLC20A2 - Sodium-dependent phosphate transporter 2 - human protein (Function)
 
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Protein
Gene
References

 
SLC20A2 »  Sodium-dependent phosphate transporter 2
 
Protein also known as:  Gibbon ape leukemia virus receptor 2 (GLVR-2).
Gene name:  SLC20A2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 38 1
GENE REF ISO

Function

 show evidences
Overview 
Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants.  
5
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the inorganic phosphate transporter (pit) family  2.A.20.2.3  
GO molecular function 
Inorganic phosphate transmembrane transporter activitydefinition[GO:0005315] silver  
  • IEAInterPro 2 GO
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
Sodium:phosphate symporter activitydefinition[GO:0005436]  
1
  • TASPINC
Virus receptor activitydefinition[GO:0001618]  
  • IEAUniProtKB KW
GO biological process 
Phosphate ion transmembrane transportdefinition[GO:0035435]  
1
  • TASGOC
Response to virusdefinition[GO:0009615]  
  • IEAUniProtKB KW
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • TASGOC
Transportdefinition[GO:0006810]  
1
  • TASPINC
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
Sodium-coupled phosphate cotransporters  REACT_19275  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Ion transport  definition   [KW-0406]
Phosphate transport  definition   [KW-0592]
Sodium transport  definition   [KW-0739]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Molecular function 
Host cell receptor for virus entry  definition   [KW-1183]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC20A2
GenomeRNAi: 6575
PRO: PR:Q08357