MFGE8 - Lactadherin - human protein (Function)
 
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MFGE8 »  Lactadherin
 
Protein also known as:  Breast epithelial antigen BA46. Cleaved into:  Lactadherin short form; Medin.
Gene name:  MFGE8
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication.  
1
  • CuratedUniProtKB
Medin is the main constituent of aortic medial amyloid.  
1
  • CuratedUniProtKB
GO molecular function 
Integrin bindingdefinition[GO:0005178] silver  
  • IEAOrtholog Compara
Phosphatidylethanolamine bindingdefinition[GO:0008429] silver  
  • IEAOrtholog Compara
Phosphatidylserine bindingdefinition[GO:0001786] silver  
  • IEAOrtholog Compara
GO biological process 
Angiogenesisdefinition[GO:0001525]  
  • IEAUniProtKB KW
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Phagocytosis, engulfmentdefinition[GO:0006911] silver  
  • IEAOrtholog Compara
Phagocytosis, recognitiondefinition[GO:0006910] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic cell clearancedefinition[GO:2000427] silver  
  • IEAOrtholog Compara
Single fertilizationdefinition[GO:0007338]  
  • IEAUniProtKB KW
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
Amyloids  REACT_75925  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Cell adhesion  definition   [KW-0130]
Fertilization  definition   [KW-0278]
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MFGE8
GenomeRNAi: 4240
PRO: PR:Q08431