ADCY2 - Adenylate cyclase type 2 - human protein (Function)
 
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ADCY2 »  Adenylate cyclase type 2   [ EC 4.6.1.1 ]
 
Protein also known as:  ATP pyrophosphate-lyase 2.
Gene name:  ADCY2
Entry whose protein(s) existence is based on evidence at protein level
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1 43 2
GENE REF ISO

Function

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Overview 
This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.  
  • CuratedUniProtKB
GO molecular function 
Adenylate cyclase activitydefinition[GO:0004016]  
1
  • NASUniProtKB
  • ISSOrtholog Curator
Adenylate cyclase bindingdefinition[GO:0008179]  
  • ISSOrtholog Curator
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calcium- and calmodulin-responsive adenylate cyclase activitydefinition[GO:0008294] silver  
  • IEAOrtholog Compara
G-protein beta/gamma-subunit complex bindingdefinition[GO:0031683] silver  
  • IEAOrtholog Compara
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein heterodimerization activitydefinition[GO:0046982]  
  • ISSOrtholog Curator
GO biological process 
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
  • ISSOrtholog Curator
cAMP biosynthetic processdefinition[GO:0006171]  
  • ISSOrtholog Curator
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.1: ATP 3',5'-cyclic AMP + diphosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 magnesium ions per subunit (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex (By similarity). Phosphorylation by RAF1 results in its activation.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+108  
Calcium signaling pathway  hsa04020+108  
Chemokine signaling pathway  hsa04062+108  
Cholinergic synapse  hsa04725+108  
Dilated cardiomyopathy  hsa05414+108  
GABAergic synapse  hsa04727+108  
Gap junction  hsa04540+108  
Gastric acid secretion  hsa04971+108  
Glutamatergic synapse  hsa04724+108  
GnRH signaling pathway  hsa04912+108  
HTLV-I infection  hsa05166+108  
Melanogenesis  hsa04916+108  
Oocyte meiosis  hsa04114+108  
Pancreatic secretion  hsa04972+108  
Progesterone-mediated oocyte maturation  hsa04914+108  
Purine metabolism  hsa00230+108  
Salivary secretion  hsa04970+108  
Vascular smooth muscle contraction  hsa04270+108  
According to Reactome, this protein belongs to the following pathways:
Adenylate cyclase activating pathway  REACT_15312  
Adenylate cyclase inhibitory pathway  REACT_15333  
G alpha (i) signalling events  REACT_19231  
G alpha (s) signalling events  REACT_19327  
G alpha (z) signalling events  REACT_19333  
Glucagon signaling in metabolic regulation  REACT_1665  
PKA activation  REACT_15530  
PKA activation in glucagon signalling  REACT_1946  
Regulation of water balance by renal Aquaporins  REACT_24023  
 

Keywords

Biological process 
cAMP biosynthesis  definition   [KW-0115]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADCY2
GenomeRNAi: 108
PRO: PR:Q08462