ADCY2 - Adenylate cyclase type 2 - human protein (Function)
 
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ADCY2 »  Adenylate cyclase type 2   [ EC 4.6.1.1 ]
 
Protein also known as:  ATP pyrophosphate-lyase 2.
Gene name:  ADCY2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).  
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  • UniProtKB
GO molecular function 
Adenylate cyclase activitydefinition[GO:0004016]  
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  • Ortholog Curator
  • RefGenome
Adenylate cyclase bindingdefinition[GO:0008179]  
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ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Magnesium ion bindingdefinition[GO:0000287]  
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Manganese ion bindingdefinition[GO:0030145]  
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  • Ortholog Curator
Protein heterodimerization activitydefinition[GO:0046982]  
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GO biological process 
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189]  
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Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
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  • Ortholog Curator
cAMP biosynthetic processdefinition[GO:0006171]  
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  • RefGenome
  • Ortholog Curator
cAMP-mediated signalingdefinition[GO:0019933]  
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  • Ortholog Curator
  • RefGenome
Cellular response to forskolindefinition[GO:1904322]  
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  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.1: ATP 3',5'-cyclic AMP + diphosphate.  
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  • UniProtKB
It requires the following cofactor
 Mg(2+) : Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).  
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  • UniProtKB
It is regulated in the following manner
Activated by forskolin (PubMed15385642). Is not activated by calmodulin. Inhibited by calcium ions, already at micromolar concentration. Activated by the G protein alpha subunit GNAS. Activated by the G protein beta and gamma subunit complex (By similarity). Phosphorylation by RAF1 results in its activation (PubMed15385642). Phosphorylation by PKC activates the enzyme (By similarity).  
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  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+108  
Calcium signaling pathway  hsa04020+108  
Chemokine signaling pathway  hsa04062+108  
Cholinergic synapse  hsa04725+108  
Dilated cardiomyopathy  hsa05414+108  
GABAergic synapse  hsa04727+108  
Gap junction  hsa04540+108  
Gastric acid secretion  hsa04971+108  
Glutamatergic synapse  hsa04724+108  
GnRH signaling pathway  hsa04912+108  
HTLV-I infection  hsa05166+108  
Melanogenesis  hsa04916+108  
Oocyte meiosis  hsa04114+108  
Pancreatic secretion  hsa04972+108  
Progesterone-mediated oocyte maturation  hsa04914+108  
Purine metabolism  hsa00230+108  
Salivary secretion  hsa04970+108  
Vascular smooth muscle contraction  hsa04270+108  
According to Reactome, this protein belongs to the following pathways:
Adenylate cyclase activating pathway  R-HSA-170660  
Adenylate cyclase inhibitory pathway  R-HSA-170670  
G alpha (i) signalling events  R-HSA-418594  
G alpha (s) signalling events  R-HSA-418555  
G alpha (z) signalling events  R-HSA-418597  
Glucagon signaling in metabolic regulation  R-HSA-163359  
Hedgehog 'off' state  R-HSA-5610787  
PKA activation  R-HSA-163615  
PKA activation in glucagon signalling  R-HSA-164378  
Vasopressin regulates renal water homeostasis via Aquaporins  R-HSA-432040  
 

Keywords

Biological process 
cAMP biosynthesis  definition   [KW-0115]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADCY2
GenomeRNAi: 108
PRO: PR:Q08462