CD47 - Leukocyte surface antigen CD47 - human protein (Function)
 
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CD47 »  Leukocyte surface antigen CD47
 
Protein also known as:  Antigenic surface determinant protein OA3; CD antigen CD47.
Gene name:  CD47
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 33 4
GENE REF ISO

Function

 show evidences
Overview 
Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.  
3
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Thrombospondin receptor activitydefinition[GO:0070053]  
1
  • IPIBHF-UCL
GO biological process 
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Integrin-mediated signaling pathwaydefinition[GO:0007229]  
1
  • TASPINC
Opsonizationdefinition[GO:0008228] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDAUniProtKB
Positive regulation of cell-cell adhesiondefinition[GO:0022409]  
1
  • IDAUniProtKB
Positive regulation of inflammatory responsedefinition[GO:0050729] silver  
  • IEAOrtholog Compara
Positive regulation of phagocytosisdefinition[GO:0050766] silver  
  • IEAOrtholog Compara
Positive regulation of T cell activationdefinition[GO:0050870]  
1
  • IDAUniProtKB
Response to bacteriumdefinition[GO:0009617] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
ECM-receptor interaction  hsa04512+961  
According to Reactome, this protein belongs to the following pathways:
Cell surface interactions at the vascular wall  REACT_12051  
Integrin cell surface interactions  REACT_13552  
Signal regulatory protein (SIRP) family interactions  REACT_23916  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD47
GenomeRNAi: 961
PRO: PR:Q08722