ADCY1 - Adenylate cyclase type 1 - human protein (Function)
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ADCY1 »  Adenylate cyclase type 1   [ EC ]
Protein also known as:  Ca(2+)/calmodulin-activated adenylyl cyclase.
Gene name:  ADCY1
Entry whose protein(s) existence is based on evidence at protein level
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This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calcium- and calmodulin-responsive adenylate cyclase activitydefinition[GO:0008294]  
  • NASUniProtKB
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Axonogenesisdefinition[GO:0007409] silver  
  • IEAOrtholog Compara
cAMP biosynthetic processdefinition[GO:0006171] silver  
  • IEAOrtholog Compara
Circadian rhythmdefinition[GO:0007623] silver  
  • IEAOrtholog Compara
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Long-term memorydefinition[GO:0007616] silver  
  • IEAOrtholog Compara
Regulation of circadian rhythmdefinition[GO:0042752]  
  • ISSOrtholog Curator
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to lithium iondefinition[GO:0010226] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC ATP 3',5'-cyclic AMP + diphosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 magnesium ions per subunit (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by calcium/calmodulin. Inhibited by the G protein beta and gamma subunit complex.  
  • CuratedUniProtKB
More information is available from:
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+107  
Bile secretion  hsa04976+107  
Calcium signaling pathway  hsa04020+107  
Chagas disease (American trypanosomiasis)  hsa05142+107  
Chemokine signaling pathway  hsa04062+107  
Cholinergic synapse  hsa04725+107  
GABAergic synapse  hsa04727+107  
Gap junction  hsa04540+107  
Gastric acid secretion  hsa04971+107  
Glutamatergic synapse  hsa04724+107  
GnRH signaling pathway  hsa04912+107  
HTLV-I infection  hsa05166+107  
Long-term potentiation  hsa04720+107  
Melanogenesis  hsa04916+107  
Oocyte meiosis  hsa04114+107  
Pancreatic secretion  hsa04972+107  
Progesterone-mediated oocyte maturation  hsa04914+107  
Purine metabolism  hsa00230+107  
Salivary secretion  hsa04970+107  
Vascular smooth muscle contraction  hsa04270+107  
According to Reactome, this protein belongs to the following pathways:
Adenylate cyclase activating pathway  REACT_15312  
Adenylate cyclase inhibitory pathway  REACT_15333  
CREB phosphorylation through the activation of Adenylate Cyclase  REACT_20625  
G alpha (i) signalling events  REACT_19231  
G alpha (s) signalling events  REACT_19327  
G alpha (z) signalling events  REACT_19333  
Glucagon signaling in metabolic regulation  REACT_1665  
PKA activation  REACT_15530  
PKA activation in glucagon signalling  REACT_1946  
Regulation of water balance by renal Aquaporins  REACT_24023  


Biological process 
Biological rhythms  definition   [KW-0090]
cAMP biosynthesis  definition   [KW-0115]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: ADCY1
GenomeRNAi: 107
PRO: PR:Q08828