ITK - Tyrosine-protein kinase ITK/TSK - human protein (Function)
 
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ITK »  Tyrosine-protein kinase ITK/TSK   [ EC 2.7.10.2 ]
 
Protein also known as:  Interleukin-2-inducible T-cell kinase (IL-2-inducible T-cell kinase).
Gene name:  ITK
Entry whose protein(s) existence is based on evidence at protein level
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1 79 1
GENE REF ISO

Function

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Overview 
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.  
3
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Activation of phospholipase C activitydefinition[GO:0007202]  
  • ISSOrtholog Curator
Adaptive immune responsedefinition[GO:0002250]  
  • ISSOrtholog Curator
Cellular defense responsedefinition[GO:0006968]  
1
  • TASPINC
Cytokine productiondefinition[GO:0001816]  
  • ISSOrtholog Curator
Interferon-gamma productiondefinition[GO:0032609] silver  
  • IEAOrtholog Compara
Interleukin-4 productiondefinition[GO:0032633] silver  
  • IEAOrtholog Compara
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
NK T cell differentiationdefinition[GO:0001865] silver  
  • IEAOrtholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
2
  • IDAGOC
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
T cell activationdefinition[GO:0042110]  
1
  • TASUniProtKB
T cell receptor signaling pathwaydefinition[GO:0050852]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.2: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+3702  
Leukocyte transendothelial migration  hsa04670+3702  
T cell receptor signaling pathway  hsa04660+3702  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
Immunity  definition   [KW-0391]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ITK_(gene)
GenomeRNAi: 3702
PRO: PR:Q08881
Chemistry
GuidetoPHARMACOLOGY: 2046