ITK - Tyrosine-protein kinase ITK/TSK - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
ITK »  Tyrosine-protein kinase ITK/TSK   [ EC 2.7.10.2 ]
 
Protein also known as:  Interleukin-2-inducible T-cell kinase (IL-2-inducible T-cell kinase).
Gene name:  ITK
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 131 1
GENE REF ISO

Function

 show evidences
Overview 
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.  
4
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
  • BHF-UCL
Not  Receptor bindingdefinition[GO:0005102]  
1
  • RefGenome
GO biological process 
Activation of phospholipase C activitydefinition[GO:0007202]  
1
  • Ortholog Curator
Adaptive immune responsedefinition[GO:0002250]  
2
  • RefGenome
  • Ortholog Curator
Not  B cell receptor signaling pathwaydefinition[GO:0050853]  
1
  • RefGenome
Cellular defense responsedefinition[GO:0006968]  
1
  • PINC
Cytokine productiondefinition[GO:0001816]  
1
  • Ortholog Curator
Innate immune responsedefinition[GO:0045087]  
1
  • RefGenome
Interferon-gamma productiondefinition[GO:0032609] silver  
1
  • Ortholog Compara
Interleukin-4 productiondefinition[GO:0032633] silver  
1
  • Ortholog Compara
Intracellular signal transductiondefinition[GO:0035556] silver  
1
  • InterPro 2 GO
NK T cell differentiationdefinition[GO:0001865]  
1
  • RefGenome
Peptidyl-tyrosine autophosphorylationdefinition[GO:0038083]  
1
  • RefGenome
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • RefGenome
Signal transductiondefinition[GO:0007165]  
1
  • PINC
T cell activationdefinition[GO:0042110]  
1
  • UniProtKB
T cell receptor signaling pathwaydefinition[GO:0050852]  
2
  • RefGenome
  • Ortholog Curator
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.2: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • PROSITE-ProRule
  • UniProtKB
It requires the following cofactor
 Zn(2+) : Binds 1 zinc ion per subunit.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+3702  
Leukocyte transendothelial migration  hsa04670+3702  
T cell receptor signaling pathway  hsa04660+3702  
According to Reactome, this protein belongs to the following pathways:
FCERI mediated Ca+2 mobilization  REACT_163834  
Generation of second messenger molecules  REACT_12623  
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
Immunity  definition   [KW-0391]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ITK_(gene)
GenomeRNAi: 3702
PRO: PR:Q08881
Chemistry
GuidetoPHARMACOLOGY: 2046