ACSM2A - Acyl-coenzyme A synthetase ACSM2A, mitochondrial - human protein (Function)
 
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ACSM2A »  Acyl-coenzyme A synthetase ACSM2A, mitochondrial   [ EC 6.2.1.2 ]
 
Protein also known as:  Acyl-CoA synthetase medium-chain family member 2A.
Gene name:  ACSM2A
Entry whose protein(s) existence is based on evidence at protein level
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1 25 1
GENE REF ISO

Function

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Overview 
Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Butyrate-CoA ligase activitydefinition[GO:0047760]  
1
  • IDABHF-UCL
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Fatty acid metabolic processdefinition[GO:0006631]  
  • IEAUniProtKB KW
Glucose homeostasisdefinition[GO:0042593]  
1
  • NASBHF-UCL
Medium-chain fatty-acyl-CoA metabolic processdefinition[GO:0036112]  
1
  • IDABHF-UCL
Triglyceride homeostasisdefinition[GO:0070328]  
1
  • NASBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.2.1.2: ATP + a carboxylate + CoA AMP + diphosphate + an acyl-CoA.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium or manganese.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Butanoate metabolism  hsa00650+123876  
Metabolic pathways  hsa01100+123876  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 123876
PRO: PR:Q08AH3