DMPK - Myotonin-protein kinase - human protein (Function)
 
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DMPK »  Myotonin-protein kinase   [ EC 2.7.11.1 ]  (MT-PK)
 
Protein also known as:  Myotonic dystrophy protein kinase.
Gene name:  DMPK
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Heat shock protein bindingdefinition[GO:0031072] silver  
  • IEAOrtholog Compara
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Myosin phosphatase regulator activitydefinition[GO:0017020]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
2
  • IDAUniProtKB
GO biological process 
Cellular calcium ion homeostasisdefinition[GO:0006874]  
  • ISSOrtholog Curator
Muscle cell apoptotic processdefinition[GO:0010657]  
1
  • IDAUniProtKB
Nuclear envelope organizationdefinition[GO:0006998]  
1
  • IMPUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
2
  • IDAUniProtKB
Regulation of catalytic activitydefinition[GO:0050790]  
1
  • IDAGOC
Regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contractiondefinition[GO:0014853] silver  
  • IEAOrtholog Compara
Regulation of heart contractiondefinition[GO:0008016]  
1
  • IDAUniProtKB
Regulation of myotube differentiationdefinition[GO:0010830]  
  • ISSOrtholog Curator
Regulation of skeletal muscle contraction by calcium ion signalingdefinition[GO:0014722] silver  
  • IEAOrtholog Compara
Regulation of sodium ion transportdefinition[GO:0002028] silver  
  • IEAOrtholog Compara
Regulation of synapse structural plasticitydefinition[GO:0051823] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
It is regulated in the following manner
Coiled-coil-mediated oligomerization enhances the catalytic activity. Proteolytic processing of the C-terminus may release the protein from membranes and constitute a mean to regulate the enzyme. May be regulated by HSPB2, RAC1, RAF1 and G-protein second messengers.  
4
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Myotonin-protein_kinase
GenomeRNAi: 1760
PRO: PR:Q09013
Chemistry
GuidetoPHARMACOLOGY: 1505