ABCC8 - ATP-binding cassette sub-family C member 8 - human protein (Function)
 
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Protein
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ABCC8 »  ATP-binding cassette sub-family C member 8
 
Protein also known as:  Sulfonylurea receptor 1.
Gene name:  ABCC8
Entry whose protein(s) existence is based on evidence at protein level
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1 145 3
GENE REF ISO

Function

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Overview 
Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.208.4  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activity, coupled to transmembrane movement of substancesdefinition[GO:0042626] silver  
  • IEAInterPro 2 GO
Ion channel bindingdefinition[GO:0044325]  
1
  • IPIBHF-UCL
Potassium ion transmembrane transporter activitydefinition[GO:0015079]  
1
  • TASPINC
Sulfonylurea receptor activitydefinition[GO:0008281] silver  
  • IEAInterPro 2 GO
GO biological process 
Carbohydrate metabolic processdefinition[GO:0005975]  
1
  • NASPINC
Ion transmembrane transportdefinition[GO:0034220]  
1
  • TASGOC
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • TASGOC
Potassium ion transportdefinition[GO:0006813]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
1
  • TASGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
ABC transporters  hsa02010+6833  
Type II diabetes mellitus  hsa04930+6833  
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Neuronal System  REACT_13685  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABCC8
GenomeRNAi: 6833
PRO: PR:Q09428