EP300 - Histone acetyltransferase p300 - human protein (Function)
 
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EP300 »  Histone acetyltransferase p300   [ EC 2.3.1.48 ]  (p300 HAT)
 
Protein also known as:  E1A-associated protein p300.
Gene name:  EP300
Entry whose protein(s) existence is based on evidence at protein level
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1 387 1
GENE REF ISO

Function

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Overview 
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity.  
12
  • CuratedUniProtKB
GO molecular function 
Acetyltransferase activitydefinition[GO:0016407]  
1
  • IMPUniProtKB
Activating transcription factor bindingdefinition[GO:0033613]  
1
  • IPIUniProtKB
Androgen receptor bindingdefinition[GO:0050681]  
1
  • IPIBHF-UCL
Antigen bindingdefinition[GO:0003823] silver  
  • IEAOrtholog Compara
Beta-catenin bindingdefinition[GO:0008013]  
1
  • IPIBHF-UCL
bHLH transcription factor bindingdefinition[GO:0043425] silver  
  • IEAOrtholog Compara
Chromatin bindingdefinition[GO:0003682]  
1
  • IMPUniProtKB
Chromatin DNA bindingdefinition[GO:0031490] silver  
  • IEAOrtholog Compara
Core promoter bindingdefinition[GO:0001047]  
1
  • IDAUniProtKB
DNA bindingdefinition[GO:0003677]  
1
  • IDAUniProtKB
Glucocorticoid receptor bindingdefinition[GO:0035259] silver  
  • IEAOrtholog Compara
Histone acetyltransferase activitydefinition[GO:0004402]  
2
  • IDAUniProtKB
Lysine N-acetyltransferase activitydefinition[GO:0004468]  
1
  • IDAUniProtKB
Mitogen-activated protein kinase bindingdefinition[GO:0051019] silver  
  • IEAOrtholog Compara
NF-kappaB bindingdefinition[GO:0051059] silver  
  • IEAOrtholog Compara
P53 bindingdefinition[GO:0002039] silver  
  • IEAOrtholog Compara
Peroxisome proliferator activated receptor bindingdefinition[GO:0042975] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
72
  • IPIIntAct
  • IPIUniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • IPIBHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
  • IEAOrtholog Compara
SMAD bindingdefinition[GO:0046332] silver  
  • IEAOrtholog Compara
Contributes to transcription coactivator activitydefinition[GO:0003713]  
5
  • IDABHF-UCL
  • IDAUniProtKB
Transcription factor bindingdefinition[GO:0008134]  
3
  • IPIUniProtKB
Transferase activity, transferring acyl groupsdefinition[GO:0016746]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • IMPUniProtKB
Cell cycledefinition[GO:0007049]  
  • IEAUniProtKB KW
Cellular response to hydrogen peroxidedefinition[GO:0070301] silver  
  • IEAOrtholog Compara
Cellular response to organic cyclic compounddefinition[GO:0071407] silver  
  • IEAOrtholog Compara
Digestive tract developmentdefinition[GO:0048565] silver  
  • IEAOrtholog Compara
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Histone H2B acetylationdefinition[GO:0043969]  
1
  • IDAUniProtKB
Histone H4 acetylationdefinition[GO:0043967]  
1
  • IMPUniProtKB
Internal peptidyl-lysine acetylationdefinition[GO:0018393]  
1
  • IDAUniProtKB
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatordefinition[GO:0042771]  
1
  • IDAUniProtKB
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
N-terminal peptidyl-lysine acetylationdefinition[GO:0018076]  
1
  • IDAUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDAUniProtKB
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Organ morphogenesisdefinition[GO:0009887] silver  
  • IEAOrtholog Compara
Positive regulation by host of viral transcriptiondefinition[GO:0043923]  
1
  • IDABHF-UCL
Positive regulation of axon extensiondefinition[GO:0045773] silver  
  • IEAOrtholog Compara
Positive regulation of cell deathdefinition[GO:0010942] silver  
  • IEAOrtholog Compara
Positive regulation of cell sizedefinition[GO:0045793] silver  
  • IEAOrtholog Compara
Positive regulation of collagen biosynthetic processdefinition[GO:0032967] silver  
  • IEAOrtholog Compara
Positive regulation of DNA bindingdefinition[GO:0043388] silver  
  • IEAOrtholog Compara
Positive regulation of glycoprotein biosynthetic processdefinition[GO:0010560] silver  
  • IEAOrtholog Compara
Positive regulation of protein bindingdefinition[GO:0032092] silver  
  • IEAOrtholog Compara
Positive regulation of protein import into nucleus, translocationdefinition[GO:0033160] silver  
  • IEAOrtholog Compara
Positive regulation of protein phosphorylationdefinition[GO:0001934] silver  
  • IEAOrtholog Compara
Positive regulation of protein secretiondefinition[GO:0050714] silver  
  • IEAOrtholog Compara
Positive regulation of proteolysisdefinition[GO:0045862] silver  
  • IEAOrtholog Compara
Positive regulation of sarcomere organizationdefinition[GO:0060298] silver  
  • IEAOrtholog Compara
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • IDAUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IMPUniProtKB
Positive regulation of translationdefinition[GO:0045727] silver  
  • IEAOrtholog Compara
Protein kinase B signalingdefinition[GO:0043491] silver  
  • IEAOrtholog Compara
Protein-DNA complex assemblydefinition[GO:0065004] silver  
  • IEAOrtholog Compara
Regulation of androgen receptor signaling pathwaydefinition[GO:0060765]  
1
  • IDABHF-UCL
Regulation of angiotensin metabolic processdefinition[GO:0060177] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IDAUniProtKB
Response to calcium iondefinition[GO:0051592] silver  
  • IEAOrtholog Compara
Response to cobalt iondefinition[GO:0032025] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to estrogendefinition[GO:0043627]  
1
  • IDAUniProtKB
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to fatty aciddefinition[GO:0070542] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666]  
2
  • IDAUniProtKB
Response to retinoic aciddefinition[GO:0032526] silver  
  • IEAOrtholog Compara
Response to tumor necrosis factordefinition[GO:0034612] silver  
  • IEAOrtholog Compara
Skeletal muscle tissue developmentdefinition[GO:0007519] silver  
  • IEAOrtholog Compara
Somitogenesisdefinition[GO:0001756] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.48: Acetyl-CoA + [histone] CoA + acetyl-[histone].  
2
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+2033  
Cell cycle  hsa04110+2033  
Herpes simplex infection  hsa05168+2033  
HTLV-I infection  hsa05166+2033  
Huntington's disease  hsa05016+2033  
Influenza A  hsa05164+2033  
Jak-STAT signaling pathway  hsa04630+2033  
Long-term potentiation  hsa04720+2033  
Melanogenesis  hsa04916+2033  
Notch signaling pathway  hsa04330+2033  
Pathways in cancer  hsa05200+2033  
Prostate cancer  hsa05215+2033  
Renal cell carcinoma  hsa05211+2033  
TGF-beta signaling pathway  hsa04350+2033  
Tuberculosis  hsa05152+2033  
Wnt signaling pathway  hsa04310+2033  
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Cellular responses to stress  REACT_120956  
Circadian Clock  REACT_24941  
Developmental Biology  REACT_111045  
Disease  REACT_116125  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: EP300
GenomeRNAi: 2033
PRO: PR:Q09472