EP300 - Histone acetyltransferase p300 - human protein (Function)
 
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Gene
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EP300 »  Histone acetyltransferase p300   [ EC 2.3.1.48 ]  (p300 HAT)
 
Protein also known as:  E1A-associated protein p300.
Gene name:  EP300
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity. Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter. Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed10733570, PubMed11430825, PubMed11701890, PubMed12402037, PubMed12586840, PubMed12929931, PubMed14645221, PubMed15186775, PubMed15890677, PubMed16617102, PubMed16762839, PubMed18722353, PubMed18995842, PubMed23415232, PubMed23911289, PubMed23934153, PubMed8945521). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed24939902). Acetylates MEF2D.  
21
  • UniProtKB
GO molecular function 
Acetyltransferase activitydefinition[GO:0016407]  
3
  • UniProtKB
Activating transcription factor bindingdefinition[GO:0033613]  
1
  • UniProtKB
Androgen receptor bindingdefinition[GO:0050681]  
1
  • BHF-UCL
Beta-catenin bindingdefinition[GO:0008013]  
1
  • BHF-UCL
bHLH transcription factor bindingdefinition[GO:0043425] silver  
1
  • Ortholog Compara
Chromatin bindingdefinition[GO:0003682]  
2
  • UniProtKB
Chromatin DNA bindingdefinition[GO:0031490] silver  
1
  • Ortholog Compara
Core promoter bindingdefinition[GO:0001047]  
1
  • UniProtKB
Damaged DNA bindingdefinition[GO:0003684]  
1
  • UniProtKB
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
Glucocorticoid receptor bindingdefinition[GO:0035259] silver  
1
  • Ortholog Compara
Histone acetyltransferase activitydefinition[GO:0004402]  
3
  • UniProtKB
Lysine N-acetyltransferase activity, acting on acetyl phosphate as donordefinition[GO:0004468]  
1
  • UniProtKB
Mitogen-activated protein kinase bindingdefinition[GO:0051019] silver  
1
  • Ortholog Compara
NF-kappaB bindingdefinition[GO:0051059] silver  
1
  • Ortholog Compara
Nuclear hormone receptor bindingdefinition[GO:0035257]  
1
  • UniProtKB
P53 bindingdefinition[GO:0002039] silver  
1
  • Ortholog Compara
Peroxisome proliferator activated receptor bindingdefinition[GO:0042975] silver  
1
  • Ortholog Compara
Pre-mRNA intronic bindingdefinition[GO:0097157] silver  
1
  • Ortholog Compara
Protein antigen bindingdefinition[GO:1990405] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
84
  • UniProtKB
  • IntAct
  • AgBase
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • MGI
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • BHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
1
  • Ortholog Compara
RNA polymerase II core promoter sequence-specific DNA bindingdefinition[GO:0000979] silver  
1
  • Ortholog Compara
SMAD bindingdefinition[GO:0046332] silver  
1
  • Ortholog Compara
Contributes to transcription coactivator activitydefinition[GO:0003713]  
5
  • BHF-UCL
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
3
  • UniProtKB
Transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingdefinition[GO:0001228] silver  
1
  • Ortholog Compara
Transferase activity, transferring acyl groupsdefinition[GO:0016746]  
1
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB
B cell differentiationdefinition[GO:0030183] silver  
1
  • Ortholog Compara
Cellular response to cAMPdefinition[GO:0071320] silver  
1
  • Ortholog Compara
Cellular response to dexamethasone stimulusdefinition[GO:0071549] silver  
1
  • Ortholog Compara
Cellular response to drugdefinition[GO:0035690] silver  
1
  • Ortholog Compara
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
1
  • Ortholog Compara
Cellular response to hydrogen peroxidedefinition[GO:0070301] silver  
1
  • Ortholog Compara
Cellular response to mineralocorticoid stimulusdefinition[GO:0071389] silver  
1
  • Ortholog Compara
Cellular response to nerve growth factor stimulusdefinition[GO:1990090] silver  
1
  • Ortholog Compara
Cellular response to retinoic aciddefinition[GO:0071300] silver  
1
  • Ortholog Compara
Cellular response to trichostatin Adefinition[GO:0035984] silver  
1
  • Ortholog Compara
Cellular response to UVdefinition[GO:0034644]  
1
  • UniProtKB
Circadian rhythmdefinition[GO:0007623]  
1
  • Ortholog Curator
Digestive tract developmentdefinition[GO:0048565] silver  
1
  • Ortholog Compara
Fat cell differentiationdefinition[GO:0045444]  
1
  • Ortholog Curator
Heart developmentdefinition[GO:0007507] silver  
1
  • Ortholog Compara
Histone H2B acetylationdefinition[GO:0043969]  
1
  • UniProtKB
Histone H3 acetylationdefinition[GO:0043966] silver  
1
  • Ortholog Compara
Histone H4 acetylationdefinition[GO:0043967]  
1
  • UniProtKB
Internal peptidyl-lysine acetylationdefinition[GO:0018393]  
1
  • UniProtKB
Internal protein amino acid acetylationdefinition[GO:0006475]  
1
  • UniProtKB
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatordefinition[GO:0042771]  
1
  • UniProtKB
Liver developmentdefinition[GO:0001889] silver  
1
  • Ortholog Compara
Lung developmentdefinition[GO:0030324] silver  
1
  • Ortholog Compara
Megakaryocyte developmentdefinition[GO:0035855] silver  
1
  • Ortholog Compara
Memorydefinition[GO:0007613] silver  
1
  • Ortholog Compara
N-terminal peptidyl-lysine acetylationdefinition[GO:0018076]  
1
  • UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154] silver  
1
  • Ortholog Compara
Negative regulation of miRNA metabolic processdefinition[GO:2000629] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • UniProtKB
Nervous system developmentdefinition[GO:0007399]  
1
  • PINC
Organ morphogenesisdefinition[GO:0009887] silver  
1
  • Ortholog Compara
Platelet formationdefinition[GO:0030220] silver  
1
  • Ortholog Compara
Positive regulation by host of viral transcriptiondefinition[GO:0043923]  
1
  • BHF-UCL
Positive regulation of axon extensiondefinition[GO:0045773] silver  
1
  • Ortholog Compara
Positive regulation of cell deathdefinition[GO:0010942] silver  
1
  • Ortholog Compara
Positive regulation of cell sizedefinition[GO:0045793] silver  
1
  • Ortholog Compara
Positive regulation of collagen biosynthetic processdefinition[GO:0032967] silver  
1