EP300 - Histone acetyltransferase p300 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
EP300 »  Histone acetyltransferase p300   [ EC 2.3.1.48 ]  (p300 HAT)
 
Protein also known as:  E1A-associated protein p300.
Gene name:  EP300
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 434 1
GENE REF ISO

Function

 show evidences
Overview 
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity. Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter. Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed10733570, PubMed11430825, PubMed11701890, PubMed12402037, PubMed12586840, PubMed12929931, PubMed14645221, PubMed15186775, PubMed15890677, PubMed16617102, PubMed16762839, PubMed18722353, PubMed18995842, PubMed23415232, PubMed23911289, PubMed23934153, PubMed8945521). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed24939902).  
20
  • UniProtKB
GO molecular function 
Acetyltransferase activitydefinition[GO:0016407]  
3
  • UniProtKB
Activating transcription factor bindingdefinition[GO:0033613]  
1
  • UniProtKB
Androgen receptor bindingdefinition[GO:0050681]  
1
  • BHF-UCL
Beta-catenin bindingdefinition[GO:0008013]  
1
  • BHF-UCL
Chromatin bindingdefinition[GO:0003682]  
2
  • UniProtKB
Chromatin DNA bindingdefinition[GO:0031490] silver  
1
  • Ortholog Compara
Core promoter bindingdefinition[GO:0001047]  
1
  • UniProtKB
Damaged DNA bindingdefinition[GO:0003684]  
1
  • UniProtKB
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
Histone acetyltransferase activitydefinition[GO:0004402]  
3
  • UniProtKB
Lysine N-acetyltransferase activity, acting on acetyl phosphate as donordefinition[GO:0004468]  
1
  • UniProtKB
Nuclear hormone receptor bindingdefinition[GO:0035257]  
1
  • UniProtKB
P53 bindingdefinition[GO:0002039] silver  
1
  • Ortholog Compara
Pre-mRNA intronic bindingdefinition[GO:0097157] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
81
  • UniProtKB
  • IntAct
  • AgBase
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • MGI
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • BHF-UCL
RNA polymerase II core promoter sequence-specific DNA bindingdefinition[GO:0000979] silver  
1
  • Ortholog Compara
Contributes to transcription coactivator activitydefinition[GO:0003713]  
5
  • BHF-UCL
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
3
  • UniProtKB
Transferase activity, transferring acyl groupsdefinition[GO:0016746]  
1
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB
Cellular response to UVdefinition[GO:0034644]  
1
  • UniProtKB
Circadian rhythmdefinition[GO:0007623]  
1
  • Ortholog Curator
Heart developmentdefinition[GO:0007507] silver  
1
  • Ortholog Compara
Histone H2B acetylationdefinition[GO:0043969]  
1
  • UniProtKB
Histone H4 acetylationdefinition[GO:0043967]  
1
  • UniProtKB
Internal peptidyl-lysine acetylationdefinition[GO:0018393]  
1
  • UniProtKB
Internal protein amino acid acetylationdefinition[GO:0006475]  
1
  • UniProtKB
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatordefinition[GO:0042771]  
1
  • UniProtKB
Lung developmentdefinition[GO:0030324] silver  
1
  • Ortholog Compara
N-terminal peptidyl-lysine acetylationdefinition[GO:0018076]  
1
  • UniProtKB
Negative regulation of protein stabilizationdefinition[GO:1903993]  
1
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • UniProtKB
Nervous system developmentdefinition[GO:0007399]  
1
  • PINC
Organ morphogenesisdefinition[GO:0009887] silver  
1
  • Ortholog Compara
Positive regulation by host of viral transcriptiondefinition[GO:0043923]  
1
  • BHF-UCL
Positive regulation of protein bindingdefinition[GO:0032092] silver  
1
  • Ortholog Compara
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
3
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responsedefinition[GO:0006990]  
1
  • Ortholog Curator
Protein acetylationdefinition[GO:0006473]  
2
  • UniProtKB
  • ParkinsonsUK-UCL
Protein stabilizationdefinition[GO:0050821]  
1
  • Ortholog Curator
Regulation of androgen receptor signaling pathwaydefinition[GO:0060765]  
1
  • BHF-UCL
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Regulation of tubulin deacetylationdefinition[GO:0090043]  
1
  • UniProtKB
Response to estrogendefinition[GO:0043627]  
1
  • UniProtKB
Response to hypoxiadefinition[GO:0001666]  
2
  • UniProtKB
Skeletal muscle tissue developmentdefinition[GO:0007519] silver  
1
  • Ortholog Compara
Somitogenesisdefinition[GO:0001756] silver  
1
  • Ortholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.48: Acetyl-CoA + [histone] CoA + acetyl-[histone].