BST1 - ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 - human protein (Function)
 
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Protein
Gene
References

 
BST1 »  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2   [ EC 3.2.2.6 ]
 
Protein also known as:  Bone marrow stromal antigen 1 (BST-1); CD antigen CD157.
Gene name:  BST1
Family name: ADP-ribosyl cyclase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.  
1
  • CuratedUniProtKB
GO molecular function 
NAD(P)+ nucleosidase activitydefinition[GO:0050135]  
  • IEAEC 2 GO
NAD+ nucleosidase activitydefinition[GO:0003953] silver  
  • IEAInterPro 2 GO
Transferase activitydefinition[GO:0016740]  
  • IEAUniProtKB KW
GO biological process 
Humoral immune responsedefinition[GO:0006959]  
1
  • TASPINC
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.2.2.6: NAD(+) + H(2)O ADP-D-ribose + nicotinamide.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+683  
Metabolic pathways  hsa01100+683  
Nicotinate and nicotinamide metabolism  hsa00760+683  
Pancreatic secretion  hsa04972+683  
Salivary secretion  hsa04970+683  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BST1
GenomeRNAi: 683
PRO: PR:Q10588