FUT2 - Galactoside 2-alpha-L-fucosyltransferase 2 - human protein (Function)
 
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FUT2 »  Galactoside 2-alpha-L-fucosyltransferase 2   [ EC 2.4.1.69 ]
 
Protein also known as:  GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2.
Gene name:  FUT2
Family name: Glycosyltransferase 11
Entry whose protein(s) existence is based on evidence at transcript level
extend overview
1 58 2
GENE REF ISO

Function

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Overview 
Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.  
  • CuratedUniProtKB
GO molecular function 
Fucosyltransferase activitydefinition[GO:0008417]  
1
  • TASPINC
Galactoside 2-alpha-L-fucosyltransferase activitydefinition[GO:0008107]  
1
  • TASUniProtKB
GO biological process 
Carbohydrate metabolic processdefinition[GO:0005975]  
1
  • TASPINC
L-fucose catabolic processdefinition[GO:0042355]  
1
  • NASUniProtKB
Protein glycosylationdefinition[GO:0006486]  
1
  • TASUniProtKB
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.69: GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 11  GT11  
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycosphingolipid biosynthesis - globo series  hsa00603+2524  
Glycosphingolipid biosynthesis - lacto and neolacto series  hsa00601+2524  
Metabolic pathways  hsa01100+2524  
Note 
There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Blood group antigen  definition   [KW-0095]
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FUT2
GenomeRNAi: 2524
PRO: PR:Q10981