ST3GAL3 - CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase - human protein (Function)
 
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Protein
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References

 
ST3GAL3 »  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase   [ EC 2.4.99.6 ]
 
Protein also known as:  Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase.
Gene name:  ST3GAL3
Family name: Glycosyltransferase 29
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- or NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Beta-galactoside (CMP) alpha-2,3-sialyltransferase activitydefinition[GO:0003836] silver  
  • IEAOrtholog Compara
N-acetyllactosaminide alpha-2,3-sialyltransferase activitydefinition[GO:0008118]  
  • IEAEC 2 GO
GO biological process 
Sialylationdefinition[GO:0097503]  
1
  • TASGOC
  • IEAInterPro 2 GO
  • IEAOrtholog Compara
  • IEAEC 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.99.6: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-glycoprotein CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-glycoprotein.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 29  GT29  
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycosaminoglycan biosynthesis - keratan sulfate  hsa00533+6487  
Glycosphingolipid biosynthesis - lacto and neolacto series  hsa00601+6487  
Metabolic pathways  hsa01100+6487  
Other types of O-glycan biosynthesis  hsa00514+6487  
According to Reactome, this protein belongs to the following pathways:
Keratan sulfate biosynthesis  REACT_121120  
Pre-NOTCH Processing in Golgi  REACT_118798  
Sialic acid metabolism  REACT_200874  
Termination of O-glycan biosynthesis  REACT_115835  
 
More information is available from:
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ST3GAL3
GenomeRNAi: 6487
PRO: PR:Q11203