ARHGEF5 - Rho guanine nucleotide exchange factor 5 - human protein (Function)
 
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ARHGEF5 »  Rho guanine nucleotide exchange factor 5
 
Protein also known as:  Transforming immortalized mammary oncogene.
Gene name:  ARHGEF5
Entry whose protein(s) existence is based on evidence at protein level
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1 48 2
GENE REF ISO

Function

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GO molecular function 
GTP bindingdefinition[GO:0005525]  
1
  • PINC
Guanyl-nucleotide exchange factor activitydefinition[GO:0005085]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • UniProtKB
  • IntAct
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089] silver  
1
  • InterPro 2 GO
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
1
  • Ortholog Compara
Intracellular signal transductiondefinition[GO:0035556] silver  
1
  • InterPro 2 GO
Myeloid dendritic cell chemotaxisdefinition[GO:0002408] silver  
1
  • Ortholog Compara
Positive regulation of GTPase activitydefinition[GO:0043547] silver  
1
  • Ortholog Compara
Positive regulation of JUN kinase activitydefinition[GO:0043507]  
1
  • UniProtKB
Positive regulation of podosome assemblydefinition[GO:0071803] silver  
1
  • Ortholog Compara
Positive regulation of protein importdefinition[GO:1904591]  
1
  • UniProtKB
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • UniProtKB
Positive regulation of stress fiber assemblydefinition[GO:0051496]  
1
  • UniProtKB
Regulation of actin cytoskeleton organizationdefinition[GO:0032956]  
1
  • UniProtKB
Regulation of cytoskeleton organizationdefinition[GO:0051493]  
1
  • UniProtKB
Not  Regulation of ERK1 and ERK2 cascadedefinition[GO:0070372]  
1
  • UniProtKB
Regulation of GTPase activitydefinition[GO:0043087]  
1
  • MGI
Regulation of Rho protein signal transductiondefinition[GO:0035023] silver  
1
  • InterPro 2 GO
 

Keywords

Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ARHGEF5
GenomeRNAi: 7984
PRO: PR:Q12774