EFEMP1 - EGF-containing fibulin-like extracellular matrix protein 1 - human protein (Function)
 
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EFEMP1 »  EGF-containing fibulin-like extracellular matrix protein 1
 
Protein also known as:  Extracellular protein S1-5.
Gene name:  EFEMP1
Family name: Fibulin
Entry whose protein(s) existence is based on evidence at protein level
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1 45 5
GENE REF ISO

Function

 show evidences
Overview 
Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.  
3
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Epidermal growth factor receptor bindingdefinition[GO:0005154]  
1
  • IDAUniProtKB
Epidermal growth factor-activated receptor activitydefinition[GO:0005006]  
1
  • IDAUniProtKB
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
  • IPIIntAct
GO biological process 
Epidermal growth factor receptor signaling pathwaydefinition[GO:0007173]  
1
  • IDAUniProtKB
Negative regulation of chondrocyte differentiationdefinition[GO:0032331]  
1
  • IDAUniProtKB
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • IDAUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IDAUniProtKB
Visual perceptiondefinition[GO:0007601]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Extracellular matrix organization  REACT_118779  
Note 
Up-regulated in malignant gliomas. May increase glioma cell adhesiveness and invasive properties.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: EFEMP1
GenomeRNAi: 2202
PRO: PR:Q12805