KCNH2 - Potassium voltage-gated channel subfamily H member 2 - human protein (Function)
 
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KCNH2 »  Potassium voltage-gated channel subfamily H member 2
 
Protein also known as:  Voltage-gated potassium channel subunit Kv11.1.
Gene name:  KCNH2
Entry whose protein(s) existence is based on evidence at protein level
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1 363 6
GENE REF ISO

Function

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Overview 
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.20.1  
GO molecular function 
Delayed rectifier potassium channel activitydefinition[GO:0005251]  
1
  • IDABHF-UCL
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Inward rectifier potassium channel activitydefinition[GO:0005242]  
2
  • IDABHF-UCL
Phosphorelay sensor kinase activitydefinition[GO:0000155] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIBHF-UCL
Voltage-gated potassium channel activitydefinition[GO:0005249]  
2
  • IDABHF-UCL
Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationdefinition[GO:1902282]  
1
  • IMPBHF-UCL
GO biological process 
Cardiac muscle contractiondefinition[GO:0060048]  
1
  • IMPBHF-UCL
Cellular response to drugdefinition[GO:0035690]  
1
  • IDABHF-UCL
Membrane depolarization during action potentialdefinition[GO:0086010]  
1
  • IDABHF-UCL
Membrane repolarization during action potentialdefinition[GO:0086011]  
3
  • IDABHF-UCL
Membrane repolarization during cardiac muscle cell action potentialdefinition[GO:0086013]  
1
  • IMPBHF-UCL
Negative regulation of potassium ion exportdefinition[GO:1902303]  
2
  • IDABHF-UCL
Negative regulation of potassium ion transmembrane transportdefinition[GO:1901380]  
2
  • IDABHF-UCL
Positive regulation of potassium ion transmembrane transportdefinition[GO:1901381]  
1
  • IDABHF-UCL
Potassium ion exportdefinition[GO:0071435]  
1
  • IDABHF-UCL
Potassium ion homeostasisdefinition[GO:0055075]  
2
  • IDABHF-UCL
Potassium ion transmembrane transportdefinition[GO:0071805]  
5
  • IDABHF-UCL
Regulation of heart rate by cardiac conductiondefinition[GO:0086091]  
2
  • IMPBHF-UCL
  • IMPMGI
Regulation of heart rate by hormonedefinition[GO:0003064]  
1
  • TASBHF-UCL
Regulation of membrane potentialdefinition[GO:0042391]  
2
  • IDABHF-UCL
Regulation of membrane repolarizationdefinition[GO:0060306]  
2
  • IDABHF-UCL
Regulation of potassium ion transmembrane transportdefinition[GO:1901379]  
1
  • IDABHF-UCL
Regulation of ventricular cardiac muscle cell membrane repolarizationdefinition[GO:0060307]  
1
  • IMPBHF-UCL
Ventricular cardiac muscle cell action potentialdefinition[GO:0086005]  
1
  • IMPBHF-UCL
Pathways 
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: HERG
GenomeRNAi: 3757
PRO: PR:Q12809
Chemistry
GuidetoPHARMACOLOGY: 572