BPTF - Nucleosome-remodeling factor subunit BPTF - human protein (Function)
 
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BPTF »  Nucleosome-remodeling factor subunit BPTF
 
Gene name:  BPTF
Family name: PBTF
Entry whose protein(s) existence is based on evidence at protein level
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1 56 3
GENE REF ISO

Function

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Overview 
Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.  
  • CuratedUniProtKB
GO molecular function 
Contributes to DNA-dependent ATPase activitydefinition[GO:0008094]  
1
  • IDAHGNC
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIHGNC
Sequence-specific DNA bindingdefinition[GO:0043565]  
2
  • IMPHGNC
Transcription factor bindingdefinition[GO:0008134]  
1
  • IDAMGI
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
  • IEAOrtholog Compara
ATP catabolic processdefinition[GO:0006200]  
1
  • IDAGOC
Brain developmentdefinition[GO:0007420]  
1
  • IMPHGNC
Chromatin remodelingdefinition[GO:0006338]  
1
  • IDAHGNC
Embryonic placenta developmentdefinition[GO:0001892] silver  
  • IEAOrtholog Compara
Endoderm developmentdefinition[GO:0007492] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDAMGI
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IMPHGNC
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IMPHGNC
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • IMPHGNC
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BPTF
GenomeRNAi: 2186
PRO: PR:Q12830