STX4 - Syntaxin-4 - human protein (Function)
 
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Protein
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STX4 »  Syntaxin-4
 
Protein also known as:  Renal carcinoma antigen NY-REN-31.
Gene name:  STX4
Family name: Syntaxin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the synaptosomal vesicle fusion pore (svf-pore) family  1.F.1.1.1  
GO molecular function 
Protein bindingdefinition[GO:0005515]  
5
  • UniProtKB
  • IntAct
SNAP receptor activitydefinition[GO:0005484]  
1
  • RefGenome
SNARE bindingdefinition[GO:0000149]  
1
  • RefGenome
Sphingomyelin phosphodiesterase activator activitydefinition[GO:0016230]  
1
  • UniProtKB
GO biological process 
Intracellular protein transportdefinition[GO:0006886]  
1
  • RefGenome
Long-term synaptic potentiationdefinition[GO:0060291]  
1
  • UniProtKB
Organelle fusiondefinition[GO:0048284]  
1
  • UniProtKB
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • UniProtKB
Positive regulation of cell adhesiondefinition[GO:0045785]  
1
  • UniProtKB
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • UniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • UniProtKB
Positive regulation of chemotaxisdefinition[GO:0050921]  
1
  • UniProtKB
Positive regulation of eosinophil degranulationdefinition[GO:0043311]  
1
  • UniProtKB
Positive regulation of establishment of protein localization to plasma membranedefinition[GO:0090004]  
1
  • UniProtKB
Positive regulation of immunoglobulin secretiondefinition[GO:0051024]  
1
  • UniProtKB
Positive regulation of insulin secretion involved in cellular response to glucose stimulusdefinition[GO:0035774]  
2
  • UniProtKB
Positive regulation of protein localization to cell surfacedefinition[GO:2000010]  
1
  • UniProtKB
Positive regulation of protein localization to plasma membranedefinition[GO:1903078]  
2
  • UniProtKB
Regulation of exocytosisdefinition[GO:0017157]  
1
  • UniProtKB
Regulation of extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:1902041]  
1
  • UniProtKB
Response to hydroperoxidedefinition[GO:0033194]  
1
  • UniProtKB
SNARE complex assemblydefinition[GO:0035493] silver  
1
  • Ortholog Compara
Synaptic vesicle fusion to presynaptic membranedefinition[GO:0031629]  
1
  • RefGenome
Vesicle dockingdefinition[GO:0048278]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
SNARE interactions in vesicular transport  hsa04130+6810  
Vasopressin-regulated water reabsorption  hsa04962+6810  
According to Reactome, this protein belongs to the following pathways:
Clathrin derived vesicle budding  REACT_19187  
Disinhibition of SNARE formation  REACT_1178  
Translocation of GLUT4 to the plasma membrane  REACT_147867  
 

Keywords

Biological process 
Neurotransmitter transport  definition   [KW-0532]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: STX4
GenomeRNAi: 6810
PRO: PR:Q12846