STX4 - Syntaxin-4 - human protein (Function)
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STX4 »  Syntaxin-4
Protein also known as:  Renal carcinoma antigen NY-REN-31.
Gene name:  STX4
Family name: Syntaxin
Entry whose protein(s) existence is based on evidence at protein level
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Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the synaptosomal vesicle fusion pore (svf-pore) family  1.F.1.1.1  
GO molecular function 
Protein bindingdefinition[GO:0005515]  
  • IPIIntAct
  • IPIUniProtKB
SNAP receptor activitydefinition[GO:0005484] silver  
  • IEAInterPro 2 GO
SNARE bindingdefinition[GO:0000149] silver  
  • IEAOrtholog Compara
GO biological process 
Intracellular protein transportdefinition[GO:0006886] silver  
  • IEAInterPro 2 GO
Neurotransmitter transportdefinition[GO:0006836]  
  • IEAUniProtKB KW
According to KEGG, this protein belongs to the following pathways:
SNARE interactions in vesicular transport  hsa04130+6810  
Vasopressin-regulated water reabsorption  hsa04962+6810  
According to Reactome, this protein belongs to the following pathways:
Clathrin derived vesicle budding  REACT_19187  
Disinhibition of SNARE formation  REACT_1178  
Translocation of GLUT4 to the plasma membrane  REACT_147867  


Biological process 
Neurotransmitter transport  definition   [KW-0532]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: STX4
GenomeRNAi: 6810
PRO: PR:Q12846