MAP3K12 - Mitogen-activated protein kinase kinase kinase 12 - human protein (Function)
 
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MAP3K12 »  Mitogen-activated protein kinase kinase kinase 12   [ EC 2.7.11.25 ]
 
Protein also known as:  Dual leucine zipper bearing kinase (DLK).
Gene name:  MAP3K12
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.  
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  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
MAP kinase kinase kinase activitydefinition[GO:0004709]  
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  • EC 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein homodimerization activitydefinition[GO:0042803]  
1
  • Ortholog Curator
Protein kinase activitydefinition[GO:0004672]  
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  • PINC
Protein kinase bindingdefinition[GO:0019901]  
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  • UniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
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  • UniProtKB
  • Ortholog Curator
GO biological process 
Activation of MAPKK activitydefinition[GO:0000186] silver  
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  • InterPro 2 GO
Activation of mitophagy in response to mitochondrial depolarizationdefinition[GO:0098779]  
1
  • ParkinsonsUK-UCL
Histone phosphorylationdefinition[GO:0016572]  
1
  • Ortholog Curator
Intracellular signal transductiondefinition[GO:0035556]  
1
  • PINC
JNK cascadedefinition[GO:0007254]  
1
  • UniProtKB
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
1
  • Ortholog Curator
Peptidyl-threonine phosphorylationdefinition[GO:0018107]  
1
  • Ortholog Curator
Protein autophosphorylationdefinition[GO:0046777]  
2
  • UniProtKB
  • Ortholog Curator
Protein phosphorylationdefinition[GO:0006468]  
2
  • UniProtKB
  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.25: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
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  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
MAPK signaling pathway  hsa04010+7786  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAP3K12
GenomeRNAi: 7786
PRO: PR:Q12852
Chemistry
GuidetoPHARMACOLOGY: 2072