MERTK - Tyrosine-protein kinase Mer - human protein (Function)
 
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MERTK »  Tyrosine-protein kinase Mer   [ EC 2.7.10.1 ]
 
Protein also known as:  Receptor tyrosine kinase MerTK.
Gene name:  MERTK
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Transmembrane receptor protein tyrosine kinase activitydefinition[GO:0004714]  
1
  • EC 2 GO
GO biological process 
Apoptotic cell clearancedefinition[GO:0043277] silver  
1
  • Ortholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • PINC
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Natural killer cell differentiationdefinition[GO:0001779] silver  
1
  • Ortholog Compara
Negative regulation of leukocyte apoptotic processdefinition[GO:2000107] silver  
1
  • CACAO
Negative regulation of lymphocyte activationdefinition[GO:0051250] silver  
1
  • Ortholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
4
  • GOC
  • InterPro 2 GO
  • UniProtKB KW
  • EC 2 GO
Phagocytosisdefinition[GO:0006909]  
1
  • BHF-UCL
Platelet activationdefinition[GO:0030168] silver  
1
  • Ortholog Compara
Positive regulation of phagocytosisdefinition[GO:0050766]  
1
  • UniProtKB
Protein kinase B signalingdefinition[GO:0043491] silver  
1
  • Ortholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • PINC
Retina development in camera-type eyedefinition[GO:0060041] silver  
1
  • Ortholog Compara
Secretion by celldefinition[GO:0032940] silver  
1
  • Ortholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
1
  • Ortholog Compara
Substrate adhesion-dependent cell spreadingdefinition[GO:0034446] silver  
1
  • Ortholog Compara
Vagina developmentdefinition[GO:0060068] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • PROSITE-ProRule
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Cell surface interactions at the vascular wall  REACT_12051  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MERTK
GenomeRNAi: 10461
PRO: PR:Q12866
Chemistry
GuidetoPHARMACOLOGY: 1837