MERTK - Tyrosine-protein kinase Mer - human protein (Function)
 
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MERTK »  Tyrosine-protein kinase Mer   [ EC 2.7.10.1 ]
 
Protein also known as:  Receptor tyrosine kinase MerTK.
Gene name:  MERTK
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Transmembrane receptor protein tyrosine kinase activitydefinition[GO:0004714]  
  • IEAEC 2 GO
GO biological process 
Apoptotic cell clearancedefinition[GO:0043277] silver  
  • IEAOrtholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Natural killer cell differentiationdefinition[GO:0001779] silver  
  • IEAOrtholog Compara
Negative regulation of lymphocyte activationdefinition[GO:0051250] silver  
  • IEAOrtholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • TASGOC
  • IEAUniProtKB KW
  • IEAInterPro 2 GO
  • IEAEC 2 GO
Phagocytosisdefinition[GO:0006909]  
1
  • IMPBHF-UCL
Platelet activationdefinition[GO:0030168] silver  
  • IEAOrtholog Compara
Positive regulation of phagocytosisdefinition[GO:0050766]  
1
  • IDAUniProtKB
Protein kinase B signalingdefinition[GO:0043491] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • TASPINC
Retina development in camera-type eyedefinition[GO:0060041] silver  
  • IEAOrtholog Compara
Secretion by celldefinition[GO:0032940] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Substrate adhesion-dependent cell spreadingdefinition[GO:0034446] silver  
  • IEAOrtholog Compara
Vagina developmentdefinition[GO:0060068] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Cell surface interactions at the vascular wall  REACT_12051  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MERTK
GenomeRNAi: 10461
PRO: PR:Q12866
Chemistry
GuidetoPHARMACOLOGY: 1837