CHD3 - Chromodomain-helicase-DNA-binding protein 3 - human protein (Function)
 
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CHD3 »  Chromodomain-helicase-DNA-binding protein 3   [ EC 3.6.4.12 ]  (CHD-3)
 
Protein also known as:  Mi-2 autoantigen 240 kDa protein.
Gene name:  CHD3
Family name: SNF2/RAD54 helicase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 62 3
GENE REF ISO

Function

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Overview 
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.  
3
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
ATP-dependent DNA helicase activitydefinition[GO:0004003]  
1
  • PINC
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB KW
Helicase activitydefinition[GO:0004386]  
1
  • UniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
8
  • UniProtKB
  • IntAct
Zinc ion bindingdefinition[GO:0008270]  
1
  • UniProtKB
GO biological process 
Centrosome organizationdefinition[GO:0051297]  
1
  • UniProtKB
Chromatin assembly or disassemblydefinition[GO:0006333] silver  
1
  • Ortholog Compara
Chromatin modificationdefinition[GO:0016568]  
1
  • UniProtKB KW
DNA duplex unwindingdefinition[GO:0032508]  
1
  • GOC
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • PINC
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Spindle organizationdefinition[GO:0007051]  
1
  • UniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.12: ATP + H(2)O ADP + phosphate.  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
HDACs deacetylate histones  REACT_263923  
RNA Polymerase I Transcription Initiation  REACT_953  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CHD3
GenomeRNAi: 1107
PRO: PR:Q12873