CHD3 - Chromodomain-helicase-DNA-binding protein 3 - human protein (Function)
 
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CHD3 »  Chromodomain-helicase-DNA-binding protein 3   [ EC 3.6.4.12 ]  (CHD-3)
 
Protein also known as:  Mi-2 autoantigen 240 kDa protein.
Gene name:  CHD3
Family name: SNF2/RAD54 helicase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 55 3
GENE REF ISO

Function

 show evidences
Overview 
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATP-dependent DNA helicase activitydefinition[GO:0004003]  
1
  • TASPINC
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Helicase activitydefinition[GO:0004386]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • NASUniProtKB
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • TASGOC
Centrosome organizationdefinition[GO:0051297]  
1
  • IDAUniProtKB
Chromatin assembly or disassemblydefinition[GO:0006333] silver  
  • IEAOrtholog Compara
Chromatin modificationdefinition[GO:0016568]  
  • IEAUniProtKB KW
DNA duplex unwindingdefinition[GO:0032508]  
1
  • TASGOC
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • TASPINC
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • NASUniProtKB
Spindle organizationdefinition[GO:0007051]  
1
  • IDAUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.12: ATP + H(2)O ADP + phosphate.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CHD3
GenomeRNAi: 1107
PRO: PR:Q12873