GRIN2A - Glutamate receptor ionotropic, NMDA 2A - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
GRIN2A »  Glutamate receptor ionotropic, NMDA 2A  (GluN2A)
 
Protein also known as:  Glutamate [NMDA] receptor subunit epsilon-1.
Gene name:  GRIN2A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 120 2
GENE REF ISO

Function

 show evidences
Overview 
NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.  
1
  • UniProtKB
GO molecular function 
ATPase bindingdefinition[GO:0051117] silver  
1
  • Ortholog Compara
Cell adhesion molecule bindingdefinition[GO:0050839] silver  
1
  • Ortholog Compara
Extracellular-glutamate-gated ion channel activitydefinition[GO:0005234]  
1
  • RefGenome
Glutamate bindingdefinition[GO:0016595] silver  
1
  • Ortholog Compara
Glutamate receptor bindingdefinition[GO:0035254] silver  
1
  • Ortholog Compara
Neurotransmitter bindingdefinition[GO:0042165] silver  
1
  • Ortholog Compara
NMDA glutamate receptor activitydefinition[GO:0004972] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
  • IntAct
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Protein kinase bindingdefinition[GO:0019901] silver  
1
  • Ortholog Compara
Voltage-gated cation channel activitydefinition[GO:0022843] silver  
1
  • Ortholog Compara
Zinc ion bindingdefinition[GO:0008270]  
1
  • Ortholog Curator
GO biological process 
Action potentialdefinition[GO:0001508] silver  
1
  • Ortholog Compara
Cellular response to amino acid stimulusdefinition[GO:0071230] silver  
1
  • Ortholog Compara
Cellular response to dsRNAdefinition[GO:0071359] silver  
1
  • Ortholog Compara
Cellular response to growth factor stimulusdefinition[GO:0071363] silver  
1
  • Ortholog Compara
Cellular response to lipiddefinition[GO:0071396] silver  
1
  • Ortholog Compara
Cellular response to magnesium iondefinition[GO:0071286] silver  
1
  • Ortholog Compara
Cellular response to manganese iondefinition[GO:0071287] silver  
1
  • Ortholog Compara
Cellular response to zinc iondefinition[GO:0071294] silver  
1
  • Ortholog Compara
Cerebral cortex developmentdefinition[GO:0021987] silver  
1
  • Ortholog Compara
Excitatory postsynaptic potentialdefinition[GO:0060079] silver  
1
  • Ortholog Compara
Glutamate receptor signaling pathwaydefinition[GO:0007215]  
1
  • PINC
Hippocampus developmentdefinition[GO:0021766] silver  
1
  • Ortholog Compara
Ion transmembrane transportdefinition[GO:0034220]  
1
  • RefGenome
Ionotropic glutamate receptor signaling pathwaydefinition[GO:0035235]  
1
  • RefGenome
Learning or memorydefinition[GO:0007611]  
1
  • PINC
Positive regulation of cell deathdefinition[GO:0010942] silver  
1
  • Ortholog Compara
Protein tetramerizationdefinition[GO:0051262] silver  
1
  • Ortholog Compara
Regulation of ion transmembrane transportdefinition[GO:0034765] silver  
1
  • Ortholog Compara
Regulation of long-term neuronal synaptic plasticitydefinition[GO:0048169] silver  
1
  • Ortholog Compara
Response to aminedefinition[GO:0014075] silver  
1
  • Ortholog Compara
Response to calcium iondefinition[GO:0051592] silver  
1
  • Ortholog Compara
Response to carbohydratedefinition[GO:0009743] silver  
1
  • Ortholog Compara
Response to cocainedefinition[GO:0042220] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to ethanoldefinition[GO:0045471]  
1
  • UniProtKB
Response to fungicidedefinition[GO:0060992] silver  
1
  • Ortholog Compara
Response to light stimulusdefinition[GO:0009416] silver  
1
  • Ortholog Compara
Response to methylmercurydefinition[GO:0051597] silver  
1
  • Ortholog Compara
Response to other organismdefinition[GO:0051707] silver  
1
  • Ortholog Compara
Rhythmic processdefinition[GO:0048511] silver  
1
  • Ortholog Compara
Spinal cord developmentdefinition[GO:0021510] silver  
1
  • Ortholog Compara
Synaptic transmission, glutamatergicdefinition[GO:0035249]  
1
  • RefGenome
Transportdefinition[GO:0006810]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+2903  
Amyotrophic lateral sclerosis (ALS)  hsa05014+2903  
Calcium signaling pathway  hsa04020+2903  
Dopaminergic synapse  hsa04728+2903  
Glutamatergic synapse  hsa04724+2903  
Long-term potentiation  hsa04720+2903  
Neuroactive ligand-receptor interaction  hsa04080+2903  
Systemic lupus erythematosus  hsa05322+2903  
According to Reactome, this protein belongs to the following pathways:
CREB phosphorylation through the activation of CaMKII  R-HSA-442729  
RAF/MAP kinase cascade  R-HSA-5673001  
Ras activation uopn Ca2+ infux through NMDA receptor  R-HSA-442982  
Unblocking of NMDA receptor, glutamate binding and activation  R-HSA-438066  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GRIN2A
GenomeRNAi: 2903
PRO: PR:Q12879
Chemistry
GuidetoPHARMACOLOGY: 456