GRIN2A - Glutamate receptor ionotropic, NMDA 2A - human protein (Function)
 
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GRIN2A »  Glutamate receptor ionotropic, NMDA 2A  (GluN2A)
 
Protein also known as:  Glutamate [NMDA] receptor subunit epsilon-1.
Gene name:  GRIN2A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.  
  • CuratedUniProtKB
GO molecular function 
Calcium channel activitydefinition[GO:0005262] silver  
  • IEAOrtholog Compara
Extracellular-glutamate-gated ion channel activitydefinition[GO:0005234] silver  
  • IBARefGenome
N-methyl-D-aspartate selective glutamate receptor activitydefinition[GO:0004972] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIIntAct
Zinc ion bindingdefinition[GO:0008270]  
  • ISSOrtholog Curator
GO biological process 
Calcium ion transmembrane transportdefinition[GO:0070588] silver  
  • IEAOrtholog Compara
Directional locomotiondefinition[GO:0033058] silver  
  • IEAOrtholog Compara
Dopamine metabolic processdefinition[GO:0042417] silver  
  • IEAOrtholog Compara
Glutamate receptor signaling pathwaydefinition[GO:0007215]  
1
  • TASPINC
Ion transmembrane transportdefinition[GO:0034220] silver  
  • IBARefGenome
Ionotropic glutamate receptor signaling pathwaydefinition[GO:0035235] silver  
  • IBARefGenome
Learning or memorydefinition[GO:0007611]  
1
  • TASPINC
Memorydefinition[GO:0007613] silver  
  • IEAOrtholog Compara
Negative regulation of protein catabolic processdefinition[GO:0042177] silver  
  • IEAOrtholog Compara
Neurogenesisdefinition[GO:0022008] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Protein localizationdefinition[GO:0008104] silver  
  • IEAOrtholog Compara
Regulation of excitatory postsynaptic membrane potentialdefinition[GO:0060079] silver  
  • IEAOrtholog Compara
Regulation of sensory perception of paindefinition[GO:0051930] silver  
  • IEAOrtholog Compara
Regulation of synaptic plasticitydefinition[GO:0048167] silver  
  • IEAOrtholog Compara
Response to amphetaminedefinition[GO:0001975] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471]  
1
  • IDAUniProtKB
Response to woundingdefinition[GO:0009611] silver  
  • IEAOrtholog Compara
Sensory perception of paindefinition[GO:0019233] silver  
  • IEAOrtholog Compara
Serotonin metabolic processdefinition[GO:0042428] silver  
  • IEAOrtholog Compara
Sleepdefinition[GO:0030431] silver  
  • IEAOrtholog Compara
Startle responsedefinition[GO:0001964] silver  
  • IEAOrtholog Compara
Synaptic transmission, glutamatergicdefinition[GO:0035249] silver  
  • IBARefGenome
Transportdefinition[GO:0006810]  
1
  • TASPINC
Visual learningdefinition[GO:0008542] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+2903  
Amyotrophic lateral sclerosis (ALS)  hsa05014+2903  
Calcium signaling pathway  hsa04020+2903  
Dopaminergic synapse  hsa04728+2903  
Glutamatergic synapse  hsa04724+2903  
Long-term potentiation  hsa04720+2903  
Neuroactive ligand-receptor interaction  hsa04080+2903  
Systemic lupus erythematosus  hsa05322+2903  
According to Reactome, this protein belongs to the following pathways:
CREB phosphorylation through the activation of CaMKII  REACT_20642  
Ras activation uopn Ca2+ infux through NMDA receptor  REACT_20546  
Unblocking of NMDA receptor, glutamate binding and activation  REACT_20594  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GRIN2A
GenomeRNAi: 2903
PRO: PR:Q12879
Chemistry
GuidetoPHARMACOLOGY: 456