DPYD - Dihydropyrimidine dehydrogenase [NADP(+)] - human protein (Function)
 
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DPYD »  Dihydropyrimidine dehydrogenase [NADP(+)]   [ EC 1.3.1.2 ]  (DPD)
 
Protein also known as:  Dihydrothymine dehydrogenase.
Gene name:  DPYD
Entry whose protein(s) existence is based on evidence at protein level
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1 135 2
GENE REF ISO

Function

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Overview 
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.  
  • CuratedUniProtKB
GO molecular function 
4 iron, 4 sulfur cluster bindingdefinition[GO:0051539]  
  • IEAUniProtKB KW
Dihydroorotate oxidase activitydefinition[GO:0004158] silver  
  • IEAInterPro 2 GO
Dihydropyrimidine dehydrogenase (NADP+) activitydefinition[GO:0017113]  
4
  • IDAUniProtKB
  • ISSOrtholog Curator
Flavin adenine dinucleotide bindingdefinition[GO:0050660]  
  • ISSOrtholog Curator
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
NADP bindingdefinition[GO:0050661]  
  • ISSOrtholog Curator
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
GO biological process 
Beta-alanine biosynthetic processdefinition[GO:0019483]  
  • IEAUniPathway
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Purine nucleobase catabolic processdefinition[GO:0006145]  
1
  • IMPUniProtKB
Pyrimidine nucleobase catabolic processdefinition[GO:0006208]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
Thymidine catabolic processdefinition[GO:0006214]  
1
  • IDAUniProtKB
Thymine catabolic processdefinition[GO:0006210]  
1
  • IDAUniProtKB
UMP biosynthetic processdefinition[GO:0006222] silver  
  • IEAInterPro 2 GO
Uracil catabolic processdefinition[GO:0006212]  
2
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.3.1.2: 5,6-dihydrouracil + NADP(+) uracil + NADPH.  
  • CuratedUniProtKB
It requires the following cofactors
Binds 2 FAD.  
  • CuratedUniProtKB
Binds 2 FMN.  
  • CuratedUniProtKB
Binds 4 4Fe-4S clusters. Contains approximately 16 iron atoms per subunit (By similarity).  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
beta-Alanine metabolism  hsa00410+1806  
Drug metabolism - other enzymes  hsa00983+1806  
Metabolic pathways  hsa01100+1806  
Pantothenate and CoA biosynthesis  hsa00770+1806  
Pyrimidine metabolism  hsa00240+1806  
According to Reactome, this protein belongs to the following pathway:
Pyrimidine catabolism  REACT_1023  
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DPYD
GenomeRNAi: 1806
PRO: PR:Q12882