FAP - Seprase - human protein (Function)
 
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FAP »  Seprase   [ EC 3.4.21.- ]
 
Protein also known as:  170 kDa melanoma membrane-bound gelatinase.
Gene name:  FAP
Family name: Peptidase S9B
Entry whose protein(s) existence is based on evidence at protein level
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1 79 2
GENE REF ISO

Function

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Overview 
In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers.  
1
  • CuratedUniProtKB
GO molecular function 
Dipeptidyl-peptidase activitydefinition[GO:0008239]  
1
  • NASUniProtKB
Endopeptidase activitydefinition[GO:0004175]  
1
  • IDABHF-UCL
Metalloendopeptidase activitydefinition[GO:0004222]  
1
  • TASUniProtKB
Peptidase activitydefinition[GO:0008233]  
1
  • IDAMGI
Protease bindingdefinition[GO:0002020]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Protein dimerization activitydefinition[GO:0046983]  
1
  • NASUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • NASUniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
  • IEAInterPro 2 GO
Contributes to serine-type peptidase activitydefinition[GO:0008236]  
4
  • IDAUniProtKB
  • IMPBHF-UCL
GO biological process 
Endothelial cell migrationdefinition[GO:0043542]  
1
  • IDAUniProtKB
Negative regulation of extracellular matrix disassemblydefinition[GO:0010716]  
1
  • IDAUniProtKB
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Regulation of fibrinolysisdefinition[GO:0051917]  
1
  • ICBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.-: Degrades gelatin and heat-denatured type I and type IV collagen, but not native type I or type IV collagen. Does not cleave laminin, fibronectin, fibrin or casein.  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links