SLC10A2 - Ileal sodium/bile acid cotransporter - human protein (Function)
 
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Protein
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SLC10A2 »  Ileal sodium/bile acid cotransporter
 
Protein also known as:  Sodium/taurocholate cotransporting polypeptide, ileal.
Gene name:  SLC10A2
Entry whose protein(s) existence is based on evidence at protein level
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1 55 1
GENE REF ISO

Function

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Overview 
Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the bile acid:na(+) symporter (bass) family  2.A.28.1.2  
GO molecular function 
Bile acid:sodium symporter activitydefinition[GO:0008508] silver  
  • IEAInterPro 2 GO
GO biological process 
Sodium ion transportdefinition[GO:0006814]  
  • IEAUniProtKB KW
Transmembrane transportdefinition[GO:0055085]  
  • IEAUniProtKB KW
Transportdefinition[GO:0006810]  
2
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Bile secretion  hsa04976+6555  
According to Reactome, this protein belongs to the following pathway:
Recycling of bile acids and salts  REACT_11042  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: SLC10A2
GenomeRNAi: 6555
PRO: PR:Q12908
Chemistry
GuidetoPHARMACOLOGY: 960