FOXC1 - Forkhead box protein C1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
FOXC1 »  Forkhead box protein C1
 
Protein also known as:  Forkhead-related transcription factor 3 (FREAC-3).
Gene name:  FOXC1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 83 1
GENE REF ISO

Function

 show evidences
Overview 
Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye.  
2
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
3
  • UniProtKB
  • MGI
DNA binding, bendingdefinition[GO:0008301]  
2
  • UniProtKB
  • MGI
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705] silver  
1
  • Ortholog Compara
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • NTNU_SB
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001228]  
1
  • GO curators
Sequence-specific DNA bindingdefinition[GO:0043565]  
2
  • UniProtKB
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981]  
1
  • RefGenome
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
6
  • UniProtKB
  • MGI
Transcription factor bindingdefinition[GO:0008134]  
1
  • UniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • Ortholog Curator
GO biological process 
Artery morphogenesisdefinition[GO:0048844] silver  
1
  • Ortholog Compara
Blood vessel remodelingdefinition[GO:0001974] silver  
1
  • Ortholog Compara
Brain developmentdefinition[GO:0007420] silver  
1
  • Ortholog Compara
Camera-type eye developmentdefinition[GO:0043010] silver  
1
  • Ortholog Compara
Cardiac muscle cell proliferationdefinition[GO:0060038] silver  
1
  • Ortholog Compara
Cell differentiationdefinition[GO:0030154]  
1
  • RefGenome
Cell migrationdefinition[GO:0016477]  
1
  • UniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • UniProtKB
Collagen fibril organizationdefinition[GO:0030199] silver  
1
  • Ortholog Compara
Embryonic heart tube developmentdefinition[GO:0035050] silver  
1
  • Ortholog Compara
Eye developmentdefinition[GO:0001654]  
1
  • MGI
Germ cell migrationdefinition[GO:0008354] silver  
1
  • Ortholog Compara
Glycosaminoglycan metabolic processdefinition[GO:0030203] silver  
1
  • Ortholog Compara
Heart developmentdefinition[GO:0007507]  
1
  • MGI
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Lacrimal gland developmentdefinition[GO:0032808] silver  
1
  • Ortholog Compara
Lymph vessel developmentdefinition[GO:0001945] silver  
1
  • Ortholog Compara
Maintenance of lens transparencydefinition[GO:0036438]  
1
  • Ortholog Curator
Mesenchymal cell developmentdefinition[GO:0014031]  
1
  • Ortholog Curator
Negative regulation of angiogenesisdefinition[GO:0016525]  
1
  • Ortholog Curator
Negative regulation of apoptotic process involved in outflow tract morphogenesisdefinition[GO:1902257] silver  
1
  • Ortholog Compara
Negative regulation of lymphangiogenesisdefinition[GO:1901491]  
1
  • Ortholog Curator
Negative regulation of mitotic cell cycledefinition[GO:0045930]  
1
  • UniProtKB
Neural crest cell developmentdefinition[GO:0014032] silver  
1
  • Ortholog Compara
Notch signaling pathwaydefinition[GO:0007219] silver  
1
  • Ortholog Compara
Odontogenesis of dentin-containing toothdefinition[GO:0042475]  
1
  • UniProtKB
Ossificationdefinition[GO:0001503] silver  
1
  • Ortholog Compara
Ovarian follicle developmentdefinition[GO:0001541] silver  
1
  • Ortholog Compara
Paraxial mesoderm formationdefinition[GO:0048341] silver  
1
  • Ortholog Compara
Positive regulation of hematopoietic progenitor cell differentiationdefinition[GO:1901534]  
1
  • Ortholog Curator
Positive regulation of hematopoietic stem cell differentiationdefinition[GO:1902038]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
3
  • NTNU_SB
  • BHF-UCL
  • Ortholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
3
  • UniProtKB
  • MGI
Regulation of blood vessel sizedefinition[GO:0050880] silver  
1
  • Ortholog Compara
Regulation of organ growthdefinition[GO:0046620] silver  
1
  • Ortholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
4
  • UniProtKB
Skeletal system developmentdefinition[GO:0001501] silver  
1
  • Ortholog Compara
Somitogenesisdefinition[GO:0001756] silver  
1
  • Ortholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
1
  • Ortholog Compara
Ureteric bud developmentdefinition[GO:0001657] silver  
1
  • Ortholog Compara
Vascular endothelial growth factor receptor signaling pathwaydefinition[GO:0048010] silver  
1
  • Ortholog Compara
Vascular endothelial growth factor signaling pathwaydefinition[GO:0038084]  
1
  • Ortholog Curator
Ventricular cardiac muscle tissue morphogenesisdefinition[GO:0055010] silver  
1
  • Ortholog Compara
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Forkhead_box_C1
GenomeRNAi: 2296
PRO: PR:Q12948