DLG1 - Disks large homolog 1 - human protein (Function)
 
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Protein
Gene
References

 
DLG1 »  Disks large homolog 1
 
Protein also known as:  Synapse-associated protein 97 (SAP97).
Gene name:  DLG1
Family name: MAGUK
Entry whose protein(s) existence is based on evidence at protein level
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1 135 9
GENE REF ISO

Function

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Overview 
Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.  
6
  • CuratedUniProtKB
GO molecular function 
Cytoskeletal protein bindingdefinition[GO:0008092]  
1
  • TASPINC
Guanylate kinase activitydefinition[GO:0004385]  
1
  • TASPINC
Ion channel bindingdefinition[GO:0044325]  
1
  • IPIBHF-UCL
L27 domain bindingdefinition[GO:0097016]  
1
  • IPIBHF-UCL
Mitogen-activated protein kinase kinase bindingdefinition[GO:0031434]  
1
  • IPIUniProtKB
Phosphatase bindingdefinition[GO:0019902]  
1
  • IPIUniProtKB
Phosphoprotein phosphatase activitydefinition[GO:0004721]  
1
  • TASUniProtKB
Potassium channel regulator activitydefinition[GO:0015459]  
2
  • IDABHF-UCL
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
18
  • IPIIntAct
  • IPIUniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • IPIUniProtKB
Protein complex scaffolddefinition[GO:0032947] silver  
  • IEAOrtholog Compara
Protein kinase bindingdefinition[GO:0019901]  
3
  • IPIUniProtKB
GO biological process 
Actin filament organizationdefinition[GO:0007015]  
1
  • IDAUniProtKB
Activation of protein kinase activitydefinition[GO:0032147] silver  
  • IEAOrtholog Compara
Amyloid precursor protein metabolic processdefinition[GO:0042982] silver  
  • IEAOrtholog Compara
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
  • IEAOrtholog Compara
Cortical actin cytoskeleton organizationdefinition[GO:0030866]  
1
  • IDAUniProtKB
Dephosphorylationdefinition[GO:0016311]  
1
  • TASGOC
Embryonic skeletal system morphogenesisdefinition[GO:0048704] silver  
  • IEAOrtholog Compara
Endothelial cell proliferationdefinition[GO:0001935]  
1
  • IDAUniProtKB
Establishment or maintenance of cell polaritydefinition[GO:0007163]  
1
  • TASUniProtKB
Hard palate developmentdefinition[GO:0060022] silver  
  • IEAOrtholog Compara
Immunological synapse formationdefinition[GO:0001771] silver  
  • IEAOrtholog Compara
Lens development in camera-type eyedefinition[GO:0002088] silver  
  • IEAOrtholog Compara
Membrane raft organizationdefinition[GO:0031579] silver  
  • IEAOrtholog Compara
Mitotic cell cycle checkpointdefinition[GO:0007093]  
1
  • NASUniProtKB
Negative regulation of epithelial cell proliferationdefinition[GO:0050680] silver  
  • IEAOrtholog Compara
Negative regulation of mitotic cell cycledefinition[GO:0045930]  
1
  • IMPUniProtKB
Negative regulation of T cell proliferationdefinition[GO:0042130] silver  
  • IEAOrtholog Compara
Nucleotide phosphorylationdefinition[GO:0046939]  
1
  • TASGOC
Peristalsisdefinition[GO:0030432] silver  
  • IEAOrtholog Compara
Positive regulation of actin filament polymerizationdefinition[GO:0030838] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of establishment of protein localization to plasma membranedefinition[GO:0090004]  
1
  • IDABHF-UCL
Positive regulation of potassium ion transportdefinition[GO:0043268]  
1
  • IDABHF-UCL
Protein localization to plasma membranedefinition[GO:0072659]  
2
  • TASBHF-UCL
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • IDABHF-UCL
Regulation of sodium ion transmembrane transportdefinition[GO:1902305]  
1
  • TASBHF-UCL
Reproductive structure developmentdefinition[GO:0048608] silver  
  • IEAOrtholog Compara
Single organismal cell-cell adhesiondefinition[GO:0016337]  
1
  • IDAUniProtKB
Smooth muscle tissue developmentdefinition[GO:0048745] silver  
  • IEAOrtholog Compara
T cell activationdefinition[GO:0042110] silver  
  • IEAOrtholog Compara
T cell cytokine productiondefinition[GO:0002369] silver  
  • IEAOrtholog Compara
Tight junction assemblydefinition[GO:0070830]  
1
  • IDABHF-UCL
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
HTLV-I infection  hsa05166+1739  
T cell receptor signaling pathway  hsa04660+1739  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DLG1
GenomeRNAi: 1739
PRO: PR:Q12959