DLG1 - Disks large homolog 1 - human protein (Function)
 
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DLG1 »  Disks large homolog 1
 
Protein also known as:  Synapse-associated protein 97 (SAP97).
Gene name:  DLG1
Family name: MAGUK
Entry whose protein(s) existence is based on evidence at protein level
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1 145 9
GENE REF ISO

Function

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Overview 
Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.  
7
  • UniProtKB
GO molecular function 
Cytoskeletal protein bindingdefinition[GO:0008092]  
1
  • PINC
Guanylate kinase activitydefinition[GO:0004385]  
1
  • PINC
Ion channel bindingdefinition[GO:0044325]  
1
  • BHF-UCL
L27 domain bindingdefinition[GO:0097016]  
1
  • BHF-UCL
Mitogen-activated protein kinase kinase bindingdefinition[GO:0031434]  
1
  • UniProtKB
Phosphatase bindingdefinition[GO:0019902]  
1
  • UniProtKB
Phosphoprotein phosphatase activitydefinition[GO:0004721]  
1
  • UniProtKB
Potassium channel regulator activitydefinition[GO:0015459]  
2
  • BHF-UCL
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
19
  • IntAct
  • UniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • UniProtKB
Protein complex scaffolddefinition[GO:0032947] silver  
1
  • Ortholog Compara
Protein kinase bindingdefinition[GO:0019901]  
3
  • UniProtKB
GO biological process 
Actin filament organizationdefinition[GO:0007015]  
1
  • UniProtKB
Activation of protein kinase activitydefinition[GO:0032147] silver  
1
  • Ortholog Compara
Amyloid precursor protein metabolic processdefinition[GO:0042982] silver  
1
  • Ortholog Compara
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
1
  • Ortholog Compara
Cortical actin cytoskeleton organizationdefinition[GO:0030866]  
1
  • UniProtKB
Dephosphorylationdefinition[GO:0016311]  
1
  • GOC
Embryonic skeletal system morphogenesisdefinition[GO:0048704] silver  
1
  • Ortholog Compara
Endothelial cell proliferationdefinition[GO:0001935]  
1
  • UniProtKB
Establishment or maintenance of cell polaritydefinition[GO:0007163]  
1
  • UniProtKB
Hard palate developmentdefinition[GO:0060022] silver  
1
  • Ortholog Compara
Immunological synapse formationdefinition[GO:0001771] silver  
1
  • Ortholog Compara
Lens development in camera-type eyedefinition[GO:0002088] silver  
1
  • Ortholog Compara
Membrane raft organizationdefinition[GO:0031579] silver  
1
  • Ortholog Compara
Mitotic cell cycle checkpointdefinition[GO:0007093]  
1
  • UniProtKB
Negative regulation of epithelial cell proliferationdefinition[GO:0050680] silver  
1
  • Ortholog Compara
Negative regulation of mitotic cell cycledefinition[GO:0045930]  
1
  • UniProtKB
Negative regulation of protein kinase B signalingdefinition[GO:0051898] silver  
1
  • Ortholog Compara
Negative regulation of T cell proliferationdefinition[GO:0042130] silver  
1
  • Ortholog Compara
Nucleotide phosphorylationdefinition[GO:0046939]  
1
  • GOC
Peristalsisdefinition[GO:0030432] silver  
1
  • Ortholog Compara
Positive regulation of actin filament polymerizationdefinition[GO:0030838] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Positive regulation of establishment of protein localization to plasma membranedefinition[GO:0090004]  
1
  • BHF-UCL
Positive regulation of potassium ion transportdefinition[GO:0043268]  
1
  • BHF-UCL
Protein localization to plasma membranedefinition[GO:0072659]  
2
  • BHF-UCL
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • BHF-UCL
Regulation of myelinationdefinition[GO:0031641] silver  
1
  • Ortholog Compara
Regulation of sodium ion transmembrane transportdefinition[GO:1902305]  
1
  • BHF-UCL
Reproductive structure developmentdefinition[GO:0048608] silver  
1
  • Ortholog Compara
Single organismal cell-cell adhesiondefinition[GO:0016337]  
1
  • UniProtKB
Smooth muscle tissue developmentdefinition[GO:0048745] silver  
1
  • Ortholog Compara
T cell activationdefinition[GO:0042110] silver  
1
  • Ortholog Compara
T cell cytokine productiondefinition[GO:0002369] silver  
1
  • Ortholog Compara
Tight junction assemblydefinition[GO:0070830]  
1
  • BHF-UCL
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
HTLV-I infection  hsa05166+1739  
T cell receptor signaling pathway  hsa04660+1739  
According to Reactome, this protein belongs to the following pathways:
Activation of Ca-permeable Kainate Receptor  REACT_21346  
NrCAM interactions  REACT_22329  
Trafficking of AMPA receptors  REACT_18307  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DLG1
GenomeRNAi: 1739
PRO: PR:Q12959