DLG1 - Disks large homolog 1 - human protein (Function)
 
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Protein
Gene
References

 
DLG1 »  Disks large homolog 1
 
Protein also known as:  Synapse-associated protein 97 (SAP97).
Gene name:  DLG1
Family name: MAGUK
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 172 9
GENE REF ISO

Function

 show evidences
Overview 
Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.  
7
  • UniProtKB
GO molecular function 
Cytoskeletal protein bindingdefinition[GO:0008092]  
1
  • PINC
Guanylate kinase activitydefinition[GO:0004385]  
1
  • PINC
Ion channel bindingdefinition[GO:0044325]  
1
  • BHF-UCL
Ionotropic glutamate receptor bindingdefinition[GO:0035255]  
1
  • RefGenome
L27 domain bindingdefinition[GO:0097016]  
1
  • BHF-UCL
Mitogen-activated protein kinase kinase bindingdefinition[GO:0031434]  
1
  • UniProtKB
Phosphatase bindingdefinition[GO:0019902]  
1
  • UniProtKB
Phosphoprotein phosphatase activitydefinition[GO:0004721]  
1
  • UniProtKB
Potassium channel regulator activitydefinition[GO:0015459]  
2
  • BHF-UCL
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
20
  • IntAct
  • UniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • UniProtKB
Protein complex scaffolddefinition[GO:0032947] silver  
1
  • Ortholog Compara
Protein kinase bindingdefinition[GO:0019901]  
3
  • UniProtKB
GO biological process 
Actin filament organizationdefinition[GO:0007015]  
1
  • UniProtKB
Activation of protein kinase activitydefinition[GO:0032147] silver  
1
  • Ortholog Compara
Amyloid precursor protein metabolic processdefinition[GO:0042982] silver  
1
  • Ortholog Compara
Astral microtubule organizationdefinition[GO:0030953]  
1
  • UniProtKB
Bicellular tight junction assemblydefinition[GO:0070830]  
1
  • BHF-UCL
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
1
  • Ortholog Compara
Cellular protein complex localizationdefinition[GO:0034629]  
1
  • UniProtKB
Cortical actin cytoskeleton organizationdefinition[GO:0030866]  
1
  • UniProtKB
Cortical microtubule organizationdefinition[GO:0043622]  
1
  • UniProtKB
Embryonic skeletal system morphogenesisdefinition[GO:0048704] silver  
1
  • Ortholog Compara
Endothelial cell proliferationdefinition[GO:0001935]  
1
  • UniProtKB
Establishment of centrosome localizationdefinition[GO:0051660]  
1
  • UniProtKB
Establishment or maintenance of cell polaritydefinition[GO:0007163]  
1
  • UniProtKB
Establishment or maintenance of epithelial cell apical/basal polaritydefinition[GO:0045197]  
1
  • RefGenome
GDP metabolic processdefinition[GO:0046710]  
1
  • GOC
GMP metabolic processdefinition[GO:0046037]  
1
  • GOC
Hard palate developmentdefinition[GO:0060022] silver  
1
  • Ortholog Compara
Immunological synapse formationdefinition[GO:0001771] silver  
1
  • Ortholog Compara
Lens development in camera-type eyedefinition[GO:0002088] silver  
1
  • Ortholog Compara
Membrane raft organizationdefinition[GO:0031579] silver  
1
  • Ortholog Compara
Mitotic cell cycle checkpointdefinition[GO:0007093]  
1
  • UniProtKB
Negative regulation of epithelial cell proliferationdefinition[GO:0050680] silver  
1
  • Ortholog Compara
Negative regulation of ERK1 and ERK2 cascadedefinition[GO:0070373]  
1
  • UniProtKB
Negative regulation of mitotic cell cycledefinition[GO:0045930]  
1
  • UniProtKB
Negative regulation of p38MAPK cascadedefinition[GO:1903753]  
1
  • UniProtKB
Negative regulation of protein kinase B signalingdefinition[GO:0051898] silver  
1
  • Ortholog Compara
Negative regulation of T cell proliferationdefinition[GO:0042130] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • UniProtKB
Nervous system developmentdefinition[GO:0007399]  
1
  • RefGenome
Peristalsisdefinition[GO:0030432] silver  
1
  • Ortholog Compara
Positive regulation of actin filament polymerizationdefinition[GO:0030838] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Positive regulation of establishment of protein localization to plasma membranedefinition[GO:0090004]  
1
  • BHF-UCL
Positive regulation of potassium ion transportdefinition[GO:0043268]  
1
  • BHF-UCL
Protein dephosphorylationdefinition[GO:0006470]  
1
  • GOC
Protein localization to plasma membranedefinition[GO:0072659]  
2
  • BHF-UCL
Receptor clusteringdefinition[GO:0043113]  
1
  • RefGenome
Receptor localization to synapsedefinition[GO:0097120]  
1
  • RefGenome
Regulation of cell shapedefinition[GO:0008360]  
1
  • UniProtKB
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • BHF-UCL
Regulation of myelinationdefinition[GO:0031641] silver  
1
  • Ortholog Compara
Not  Regulation of NIK/NF-kappaB signalingdefinition[GO:1901222]  
1
  • UniProtKB
Regulation of sodium ion transmembrane transportdefinition[GO:1902305]  
1
  • BHF-UCL
Reproductive structure developmentdefinition[GO:0048608] silver  
1
  • Ortholog Compara
Single organismal cell-cell adhesiondefinition[GO:0016337]  
1
  • UniProtKB
Smooth muscle tissue developmentdefinition[GO:0048745] silver  
1
  • Ortholog Compara
Synaptic transmissiondefinition[GO:0007268]  
1
  • RefGenome
T cell activationdefinition[GO:0042110] silver  
1
  • Ortholog Compara
T cell cytokine productiondefinition[GO:0002369] silver  
1
  • Ortholog Compara
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
HTLV-I infection  hsa05166+1739  
T cell receptor signaling pathway  hsa04660+1739  
According to Reactome, this protein belongs to the following pathways:
Activation of Ca-permeable Kainate Receptor  R-HSA-451308  
NrCAM interactions  R-HSA-447038  
Trafficking of AMPA receptors  R-HSA-399719  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DLG1
GenomeRNAi: 1739
PRO: PR:Q12959