ABR - Active breakpoint cluster region-related protein - human protein (Function)
 
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ABR »  Active breakpoint cluster region-related protein
 
Gene name:  ABR
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them.  
  • CuratedUniProtKB
GO molecular function 
GTPase activator activitydefinition[GO:0005096]  
1
  • TASPINC
Rac GTPase activator activitydefinition[GO:0030675] silver  
  • IEAOrtholog Compara
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089] silver  
  • IEAInterPro 2 GO
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
  • IEAOrtholog Compara
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
  • IEAOrtholog Compara
Negative regulation of cell migrationdefinition[GO:0030336] silver  
  • IEAOrtholog Compara
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
  • IEAOrtholog Compara
Negative regulation of neutrophil degranulationdefinition[GO:0043314] silver  
  • IEAOrtholog Compara
Neuromuscular process controlling balancedefinition[GO:0050885] silver  
  • IEAOrtholog Compara
Positive regulation of phagocytosisdefinition[GO:0050766] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
GTPase activation  definition   [KW-0343]
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 29
PRO: PR:Q12979