ABR - Active breakpoint cluster region-related protein - human protein (Function)
 
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Protein
Gene
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ABR »  Active breakpoint cluster region-related protein
 
Gene name:  ABR
Entry whose protein(s) existence is based on evidence at protein level
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1 29 4
GENE REF ISO

Function

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Overview 
GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them.  
1
  • UniProtKB
GO molecular function 
GTPase activator activitydefinition[GO:0005096]  
1
  • UniProtKB KW
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089] silver  
1
  • InterPro 2 GO
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
1
  • Ortholog Compara
Brain developmentdefinition[GO:0007420] silver  
1
  • Ortholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
1
  • Ortholog Compara
Negative regulation of cell migrationdefinition[GO:0030336] silver  
1
  • Ortholog Compara
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
1
  • Ortholog Compara
Negative regulation of neutrophil degranulationdefinition[GO:0043314] silver  
1
  • Ortholog Compara
Neuromuscular process controlling balancedefinition[GO:0050885] silver  
1
  • Ortholog Compara
Positive regulation of GTPase activitydefinition[GO:0043547]  
3
  • GOC
  • UniProtKB KW
  • InterPro 2 GO
Positive regulation of phagocytosisdefinition[GO:0050766] silver  
1
  • Ortholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
G alpha (12/13) signalling events  REACT_18407  
NRAGE signals death through JNK  REACT_13638  
Rho GTPase cycle  REACT_11051  
 

Keywords

Molecular function 
GTPase activation  definition   [KW-0343]
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 29
PRO: PR:Q12979