BNIP3 - BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 - human protein (Function)
 
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BNIP3 »  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
 
Gene name:  BNIP3
Family name: NIP3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 104 1
GENE REF ISO

Function

 show evidences
Overview 
Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the bcl2/adenovirus e1b-interacting protein 3 (bnip3) family  1.A.20.1.1  
GO molecular function 
GTPase bindingdefinition[GO:0051020]  
1
  • IPIBHF-UCL
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Protein bindingdefinition[GO:0005515]  
9
  • IPIUniProtKB
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IDAUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
2
  • IDAUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • IPIMGI
Autophagic cell deathdefinition[GO:0048102] silver  
  • IEAOrtholog Compara
Brown fat cell differentiationdefinition[GO:0050873] silver  
  • IEAOrtholog Compara
Cell deathdefinition[GO:0008219]  
  • ISSOrtholog Curator
Cellular response to cobalt iondefinition[GO:0071279]  
1
  • IMPBHF-UCL
Cellular response to hydrogen peroxidedefinition[GO:0070301] silver  
  • IEAOrtholog Compara
Cellular response to hypoxiadefinition[GO:0071456]  
1
  • IMPBHF-UCL
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • IEPUniProtKB
Defense response to virusdefinition[GO:0051607]  
1
  • IDAUniProtKB
Granzyme-mediated apoptotic signaling pathwaydefinition[GO:0008626]  
1
  • IDAUniProtKB
Intrinsic apoptotic signaling pathway in response to hypoxiadefinition[GO:1990144]  
1
  • IMPBHF-UCL
Mitochondrial fragmentation involved in apoptotic processdefinition[GO:0043653]  
1
  • IDABHF-UCL
Mitochondrial outer membrane permeabilizationdefinition[GO:0097345]  
1
  • IDAUniProtKB
Mitochondrial protein catabolic processdefinition[GO:0035694]  
1
  • IMPUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • TASUniProtKB
Negative regulation of membrane potentialdefinition[GO:0045837]  
1
  • IDAUniProtKB
Negative regulation of mitochondrial fusiondefinition[GO:0010637]  
1
  • IDABHF-UCL
Neuron apoptotic processdefinition[GO:0051402]  
  • ISSOrtholog Curator
Positive regulation of apoptotic processdefinition[GO:0043065]  
2
  • IDAUniProtKB
Positive regulation of autophagydefinition[GO:0010508]  
1
  • TASUniProtKB
Positive regulation of mitochondrial fissiondefinition[GO:0090141]  
1
  • IDABHF-UCL
Positive regulation of programmed cell deathdefinition[GO:0043068]  
1
  • IDAUniProtKB
Positive regulation of protein complex disassemblydefinition[GO:0043243]  
1
  • IDABHF-UCL
Positive regulation of release of cytochrome c from mitochondriadefinition[GO:0090200]  
1
  • IDABHF-UCL
Reactive oxygen species metabolic processdefinition[GO:0072593]  
1
  • IDAUniProtKB
Regulation of mitochondrial membrane permeabilitydefinition[GO:0046902]  
1
  • IDAUniProtKB
Response to hyperoxiadefinition[GO:0055093] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666]  
  • ISSOrtholog Curator
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Legionellosis  hsa05134+664  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BNIP3
GenomeRNAi: 664
PRO: PR:Q12983