TRIM32 - E3 ubiquitin-protein ligase TRIM32 - human protein (Function)
 
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TRIM32 »  E3 ubiquitin-protein ligase TRIM32   [ EC 6.3.2.- ]
 
Protein also known as:  Tripartite motif-containing protein 32.
Gene name:  TRIM32
Family name: TRIM/RBCC
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 51 1
GENE REF ISO

Function

 show evidences
Overview 
Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.  
2
  • CuratedUniProtKB
GO molecular function 
Myosin bindingdefinition[GO:0017022]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein self-associationdefinition[GO:0043621]  
1
  • IDAUniProtKB
RNA bindingdefinition[GO:0003723]  
  • ISSOrtholog Curator
Tat protein bindingdefinition[GO:0030957]  
1
  • TASBHF-UCL
Transcription coactivator activitydefinition[GO:0003713]  
1
  • TASPINC
Translation initiation factor bindingdefinition[GO:0031369]  
  • ISSOrtholog Curator
Ubiquitin bindingdefinition[GO:0043130]  
1
  • IDAUniProtKB
Ubiquitin-protein ligase activitydefinition[GO:0004842]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Fat cell differentiationdefinition[GO:0045444]  
  • ISSOrtholog Curator
Innate immune responsedefinition[GO:0045087]  
2
  • IDAUniProtKB
  • TASBHF-UCL
Negative regulation of fibroblast proliferationdefinition[GO:0048147]  
  • ISSOrtholog Curator
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:1902230]  
1
  • IDABHF-UCL
Negative regulation of viral release from host celldefinition[GO:1902187]  
1
  • IDAUniProtKB
Negative regulation of viral transcriptiondefinition[GO:0032897]  
1
  • IDAUniProtKB
Positive regulation of cell cycledefinition[GO:0045787]  
1
  • IDABHF-UCL
Positive regulation of cell growthdefinition[GO:0030307]  
1
  • IDABHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IDABHF-UCL
Positive regulation of cell motilitydefinition[GO:2000147]  
  • ISSOrtholog Curator
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IDAUniProtKB
Positive regulation of neurogenesisdefinition[GO:0050769]  
  • ISSOrtholog Curator
Positive regulation of neuron differentiationdefinition[GO:0045666]  
  • ISSOrtholog Curator
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Positive regulation of protein catabolic processdefinition[GO:0045732]  
  • ISSOrtholog Curator
Positive regulation of proteolysisdefinition[GO:0045862]  
1
  • IDABHF-UCL
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • IDAUniProtKB
Protein polyubiquitinationdefinition[GO:0000209]  
1
  • IDABHF-UCL
Protein ubiquitinationdefinition[GO:0016567]  
1
  • IDABHF-UCL
Protein ubiquitination involved in ubiquitin-dependent protein catabolic processdefinition[GO:0042787]  
1
  • IMPUniProtKB
Response to tumor necrosis factordefinition[GO:0034612]  
  • ISSOrtholog Curator
Response to UVdefinition[GO:0009411]  
  • ISSOrtholog Curator
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathway:
Ubiquitin mediated proteolysis  hsa04120+22954  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TRIM32
GenomeRNAi: 22954
PRO: PR:Q13049