NAIP - Baculoviral IAP repeat-containing protein 1 - human protein (Function)
 
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NAIP »  Baculoviral IAP repeat-containing protein 1
 
Protein also known as:  Neuronal apoptosis inhibitory protein.
Gene name:  NAIP
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.  
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  • UniProtKB
Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.  
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  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB
Cysteine-type endopeptidase inhibitor activity involved in apoptotic processdefinition[GO:0043027]  
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  • RefGenome
Metal ion bindingdefinition[GO:0046872]  
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  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
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  • UniProtKB
Ubiquitin-protein transferase activitydefinition[GO:0004842]  
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  • RefGenome
GO biological process 
Inflammatory responsedefinition[GO:0006954]  
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  • UniProtKB KW
Inhibition of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:1990001]  
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  • RefGenome
Innate immune responsedefinition[GO:0045087]  
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  • UniProtKB KW
Negative regulation of apoptotic processdefinition[GO:0043066]  
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  • Ortholog Curator
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154]  
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  • UniProtKB
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
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  • UniProtKB
Nervous system developmentdefinition[GO:0007399]  
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  • PINC
Protein ubiquitinationdefinition[GO:0016567]  
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  • RefGenome
Regulation of signal transductiondefinition[GO:0009966]  
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  • RefGenome
Not  Spindle assembly involved in mitosisdefinition[GO:0090307]  
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  • RefGenome
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Legionellosis  hsa05134+100510692  
Legionellosis  hsa05134+4671  
NOD-like receptor signaling pathway  hsa04621+100510692  
NOD-like receptor signaling pathway  hsa04621+4671  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Innate immunity  definition   [KW-0399]
Molecular function 
Protease inhibitor  definition   [KW-0646]
Thiol protease inhibitor  definition   [KW-0789]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NAIP_(gene)
GenomeRNAi: 4671
PRO: PR:Q13075