NAIP - Baculoviral IAP repeat-containing protein 1 - human protein (Function)
 
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NAIP »  Baculoviral IAP repeat-containing protein 1
 
Protein also known as:  Neuronal apoptosis inhibitory protein.
Gene name:  NAIP
Entry whose protein(s) existence is based on evidence at protein level
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1 42 2
GENE REF ISO

Function

 show evidences
Overview 
Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.  
6
  • CuratedUniProtKB
Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.  
6
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IMPUniProtKB
Cysteine-type endopeptidase inhibitor activitydefinition[GO:0004869]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Nucleoside-triphosphatase activitydefinition[GO:0017111] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Inflammatory responsedefinition[GO:0006954]  
  • IEAUniProtKB KW
Innate immune responsedefinition[GO:0045087]  
  • IEAUniProtKB KW
Negative regulation of apoptotic processdefinition[GO:0043066]  
  • ISSOrtholog Curator
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154]  
1
  • IDAUniProtKB
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
1
  • TASUniProtKB
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Legionellosis  hsa05134+100510692  
Legionellosis  hsa05134+4671  
NOD-like receptor signaling pathway  hsa04621+100510692  
NOD-like receptor signaling pathway  hsa04621+4671  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Innate immunity  definition   [KW-0399]
Molecular function 
Protease inhibitor  definition   [KW-0646]
Thiol protease inhibitor  definition   [KW-0789]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NAIP_(gene)
GenomeRNAi: 4671
PRO: PR:Q13075