ACACA - Acetyl-CoA carboxylase 1 - human protein (Function)
 
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Protein
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ACACA »  Acetyl-CoA carboxylase 1   [ EC 6.4.1.2 ]  (ACC1)
 
Protein also known as:  ACC-alpha.
Gene name:  ACACA
Entry whose protein(s) existence is based on evidence at protein level
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1 55 4
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.  
1
  • CuratedUniProtKB
GO molecular function 
Acetyl-CoA carboxylase activitydefinition[GO:0003989]  
1
  • ISSUniProtKB
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Biotin carboxylase activitydefinition[GO:0004075]  
  • IEAEC 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
5
  • IPIUniProtKB
  • IPIIntAct
  • IPIBHF-UCL
GO biological process 
Acetyl-CoA metabolic processdefinition[GO:0006084]  
  • ISSOrtholog Curator
Fatty acid biosynthetic processdefinition[GO:0006633]  
  • ISSOrtholog Curator
Lipid homeostasisdefinition[GO:0055088] silver  
  • IEAOrtholog Compara
Malonyl-CoA biosynthetic processdefinition[GO:2001295]  
  • IEAUniPathway
Multicellular organismal protein metabolic processdefinition[GO:0044268] silver  
  • IEAOrtholog Compara
Protein homotetramerizationdefinition[GO:0051289]  
1
  • ISSUniProtKB
  • ISSOrtholog Curator
Tissue homeostasisdefinition[GO:0001894] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 6.4.1.2: ATP + acetyl-CoA + HCO(3)(-) ADP + phosphate + malonyl-CoA.  
1
  • CuratedUniProtKB
EC 6.3.4.14: ATP + biotin-[carboxyl-carrier-protein] + CO(2) ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].  
1
  • CuratedUniProtKB
It requires the following cofactors
Biotin.  
  • CuratedUniProtKB
Binds 2 manganese ions per subunit.  
  • CuratedUniProtKB
It is regulated in the following manner
By phosphorylation (By similarity). Activity is increased by oligomerization. Citrate and MID1IP1 promote oligomerization.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Fatty acid biosynthesis  hsa00061+31  
Insulin signaling pathway  hsa04910+31  
Metabolic pathways  hsa01100+31  
Propanoate metabolism  hsa00640+31  
Pyruvate metabolism  hsa00620+31  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 

Keywords

Biological process 
Fatty acid biosynthesis  definition   [KW-0275]
Fatty acid metabolism  definition   [KW-0276]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Multifunctional enzyme  definition   [KW-0511]
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q13085
Other
GeneWiki: ACACA
GenomeRNAi: 31
PRO: PR:Q13085
Chemistry
GuidetoPHARMACOLOGY: 1263