PDIA2 - Protein disulfide-isomerase A2 - human protein (Function)
 
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PDIA2 »  Protein disulfide-isomerase A2   [ EC 5.3.4.1 ]
 
Protein also known as:  Pancreas-specific protein disulfide isomerase (PDIp).
Gene name:  PDIA2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 62 2
GENE REF ISO

Function

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Overview 
Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein disulfide isomerase activitydefinition[GO:0003756]  
  • IEAEC 2 GO
Protein disulfide oxidoreductase activitydefinition[GO:0015035] silver  
  • IEAInterPro 2 GO
Steroid bindingdefinition[GO:0005496]  
  • IEAUniProtKB KW
GO biological process 
Cell redox homeostasisdefinition[GO:0045454] silver  
  • IEAInterPro 2 GO
Glycerol ether metabolic processdefinition[GO:0006662] silver  
  • IEAInterPro 2 GO
Protein foldingdefinition[GO:0006457]  
1
  • TASPINC
Protein retention in ER lumendefinition[GO:0006621]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.3.4.1: Catalyzes the rearrangement of -S-S- bonds in proteins.  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Chaperone  definition   [KW-0143]
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 64714
PRO: PR:Q13087