TRAF3 - TNF receptor-associated factor 3 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
TRAF3 »  TNF receptor-associated factor 3   [ EC 6.3.2.- ]
 
Protein also known as:  CD40 receptor-associated factor 1 (CRAF1).
Gene name:  TRAF3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 112 2
GENE REF ISO

Function

 show evidences
Overview 
Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.  
6
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
12
  • IPIIntAct
  • IPIUniProtKB
  • IPIHGNC
Protein kinase bindingdefinition[GO:0019901] silver  
  • IEAOrtholog Compara
Signal transducer activitydefinition[GO:0004871]  
2
  • TASPINC
Thioesterase bindingdefinition[GO:0031996]  
1
  • IPIUniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
Ubiquitin-protein ligase activitydefinition[GO:0004842] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Negative regulation of NF-kappaB transcription factor activitydefinition[GO:0032088]  
1
  • IMPUniProtKB
Regulation of apoptotic processdefinition[GO:0042981] silver  
  • IEAInterPro 2 GO
Regulation of cytokine productiondefinition[GO:0001817]  
  • ISSOrtholog Curator
Regulation of defense response to virusdefinition[GO:0050688]  
  • ISSOrtholog Curator
Regulation of interferon-beta productiondefinition[GO:0032648]  
  • ISSOrtholog Curator
Regulation of proteolysisdefinition[GO:0030162]  
1
  • IMPUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Toll-like receptor signaling pathwaydefinition[GO:0002224]  
  • ISSOrtholog Curator
Tumor necrosis factor-mediated signaling pathwaydefinition[GO:0033209]  
1
  • IMPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Hepatitis C  hsa05160+7187  
Herpes simplex infection  hsa05168+7187  
Pathways in cancer  hsa05200+7187  
RIG-I-like receptor signaling pathway  hsa04622+7187  
Small cell lung cancer  hsa05222+7187  
Toll-like receptor signaling pathway  hsa04620+7187  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Immunity  definition   [KW-0391]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TRAF3
GenomeRNAi: 7187
PRO: PR:Q13114