TARDBP - TAR DNA-binding protein 43 - human protein (Function)
 
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TARDBP »  TAR DNA-binding protein 43  (TDP-43)
 
Gene name:  TARDBP
Entry whose protein(s) existence is based on evidence at protein level
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1 295 1
GENE REF ISO

Function

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Overview 
DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.  
2
  • CuratedUniProtKB
GO molecular function 
Double-stranded DNA bindingdefinition[GO:0003690]  
1
  • IDABHF-UCL
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
mRNA 3'-UTR bindingdefinition[GO:0003730]  
1
  • IDABHF-UCL
Nucleotide bindingdefinition[GO:0000166] silver  
  • IEAInterPro 2 GO
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
RNA bindingdefinition[GO:0003723]  
1
  • IDABHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • TASPINC
GO biological process 
3'-UTR-mediated mRNA stabilizationdefinition[GO:0070935]  
1
  • IDABHF-UCL
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
mRNA processingdefinition[GO:0006397]  
  • IEAUniProtKB KW
Negative regulation by host of viral transcriptiondefinition[GO:0043922]  
1
  • IDABHF-UCL
RNA splicingdefinition[GO:0008380]  
1
  • IDABHF-UCL
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
mRNA processing  definition   [KW-0507]
mRNA splicing  definition   [KW-0508]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TARDBP
GenomeRNAi: 23435
PRO: PR:Q13148