FADD - FAS-associated death domain protein - human protein (Function)
 
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FADD »  FAS-associated death domain protein
 
Protein also known as:  FAS-associating death domain-containing protein.
Gene name:  FADD
Entry whose protein(s) existence is based on evidence at protein level
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1 157 1
GENE REF ISO

Function

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Overview 
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.  
4
  • CuratedUniProtKB
GO molecular function 
Death receptor bindingdefinition[GO:0005123]  
1
  • TASPINC
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Protease bindingdefinition[GO:0002020]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
32
  • IPIIntAct
  • IPIBHF-UCL
  • IPIUniProtKB
Tumor necrosis factor receptor bindingdefinition[GO:0005164] silver  
  • IEAOrtholog Compara
Tumor necrosis factor receptor superfamily bindingdefinition[GO:0032813]  
1
  • IPIUniProtKB
GO biological process 
Activation of cysteine-type endopeptidase activitydefinition[GO:0097202]  
1
  • IDABHF-UCL
Apoptotic processdefinition[GO:0006915]  
1
  • IMPUniProtKB
Apoptotic signaling pathwaydefinition[GO:0097190]  
1
  • IDABHF-UCL
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • IEPUniProtKB
Defense response to virusdefinition[GO:0051607]  
1
  • IMPUniProtKB
Extrinsic apoptotic signaling pathwaydefinition[GO:0097191]  
3
  • IDAUniProtKB
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
  • IEAOrtholog Compara
Extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:0008625]  
1
  • TASPINC
Lymph node developmentdefinition[GO:0048535]  
  • ISSOrtholog Curator
Motor neuron apoptotic processdefinition[GO:0097049] silver  
  • IEAOrtholog Compara
Necrotic cell deathdefinition[GO:0070265]  
1
  • IMPBHF-UCL
Negative regulation of activation-induced cell death of T cellsdefinition[GO:0070236]  
  • ISSOrtholog Curator
Positive regulation of activated T cell proliferationdefinition[GO:0042104]  
  • ISSOrtholog Curator
Positive regulation of adaptive immune responsedefinition[GO:0002821]  
  • ISSOrtholog Curator
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • IMPUniProtKB
Positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasationdefinition[GO:2000454]  
  • ISSOrtholog Curator
Positive regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001238]  
1
  • IMPUniProtKB
Positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:1902043] silver  
  • IEAOrtholog Compara
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IEPUniProtKB
Positive regulation of interferon-gamma productiondefinition[GO:0032729]  
  • ISSOrtholog Curator
Positive regulation of interleukin-8 productiondefinition[GO:0032757]  
1
  • IDABHF-UCL
Positive regulation of macrophage differentiationdefinition[GO:0045651]  
1
  • IMPUniProtKB
Positive regulation of proteolysisdefinition[GO:0045862]  
1
  • IDABHF-UCL
Positive regulation of T cell mediated cytotoxicitydefinition[GO:0001916]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Positive regulation of tumor necrosis factor productiondefinition[GO:0032760]  
1
  • IDABHF-UCL
Positive regulation of type I interferon-mediated signaling pathwaydefinition[GO:0060340]  
1
  • IMPUniProtKB
Protein heterooligomerizationdefinition[GO:0051291] silver  
  • IEAOrtholog Compara
Spleen developmentdefinition[GO:0048536]  
  • ISSOrtholog Curator
T cell differentiation in thymusdefinition[GO:0033077]  
  • ISSOrtholog Curator
T cell homeostasisdefinition[GO:0043029]  
  • ISSOrtholog Curator
Thymus developmentdefinition[GO:0048538]  
  • ISSOrtholog Curator
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+8772  
Apoptosis  hsa04210+8772  
Chagas disease (American trypanosomiasis)  hsa05142+8772  
Herpes simplex infection  hsa05168+8772  
Pathways in cancer  hsa05200+8772  
RIG-I-like receptor signaling pathway  hsa04622+8772  
Toll-like receptor signaling pathway  hsa04620+8772  
Tuberculosis  hsa05152+8772  
According to Reactome, this protein belongs to the following pathways:
Apoptosis  REACT_578  
Immune System  REACT_6900  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Host-virus interaction  definition   [KW-0945]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FADD
GenomeRNAi: 8772
PRO: PR:Q13158