MAP2K5 - Dual specificity mitogen-activated protein kinase kinase 5 - human protein (Function)
 
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MAP2K5 »  Dual specificity mitogen-activated protein kinase kinase 5   [ EC 2.7.12.2 ]  (MAPKK 5)
 
Protein also known as:  MAPK/ERK kinase 5 (MEK 5).
Gene name:  MAP2K5
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 33 4
GENE REF ISO

Function

 show evidences
Overview 
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
  • IPIIntAct
Protein kinase activitydefinition[GO:0004672]  
1
  • TASPINC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
Protein tyrosine kinase activitydefinition[GO:0004713]  
  • IEAUniProtKB KW
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • ISSBHF-UCL
Cellular response to growth factor stimulusdefinition[GO:0071363]  
1
  • ISSBHF-UCL
Cellular response to laminar fluid shear stressdefinition[GO:0071499]  
1
  • TASBHF-UCL
ERK5 cascadedefinition[GO:0070375] silver  
  • IEAOrtholog Compara
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Negative regulation of cell migration involved in sprouting angiogenesisdefinition[GO:0090051]  
1
  • ISSBHF-UCL
Negative regulation of chemokine (C-X-C motif) ligand 2 productiondefinition[GO:2000342]  
1
  • ISSBHF-UCL
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154]  
1
  • ISSBHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240]  
1
  • ISSBHF-UCL
Negative regulation of heterotypic cell-cell adhesiondefinition[GO:0034115]  
1
  • ISSBHF-UCL
Negative regulation of interleukin-8 biosynthetic processdefinition[GO:0045415]  
1
  • ISSBHF-UCL
Negative regulation of NF-kappaB transcription factor activitydefinition[GO:0032088]  
1
  • ISSBHF-UCL
Negative regulation of response to cytokine stimulusdefinition[GO:0060761]  
1
  • ISSBHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
  • ISSOrtholog Curator
Positive regulation of cell growthdefinition[GO:0030307] silver  
  • IEAOrtholog Compara
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
  • IEAOrtholog Compara
Positive regulation of protein metabolic processdefinition[GO:0051247]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.12.2: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Gap junction  hsa04540+5607  
MAPK signaling pathway  hsa04010+5607  
Neurotrophin signaling pathway  hsa04722+5607  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAP2K5
GenomeRNAi: 5607
PRO: PR:Q13163
Chemistry
GuidetoPHARMACOLOGY: 2066