MAPK7 - Mitogen-activated protein kinase 7 - human protein (Function)
 
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MAPK7 »  Mitogen-activated protein kinase 7   [ EC 2.7.11.24 ]  (MAPK 7)
 
Protein also known as:  Extracellular signal-regulated kinase 5 (ERK-5).
Gene name:  MAPK7
Entry whose protein(s) existence is based on evidence at protein level
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1 208 4
GENE REF ISO

Function

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Overview 
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.  
6
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
MAP kinase activitydefinition[GO:0004707]  
1
  • EC 2 GO
Mitogen-activated protein kinase bindingdefinition[GO:0051019]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
4
  • UniProtKB
  • IntAct
GO biological process 
cAMP-mediated signalingdefinition[GO:0019933]  
1
  • BHF-UCL
Cell cycledefinition[GO:0007049]  
1
  • UniProtKB KW
Cell differentiationdefinition[GO:0030154]  
1
  • UniProtKB KW
Cellular response to growth factor stimulusdefinition[GO:0071363]  
1
  • BHF-UCL
Cellular response to hydrogen peroxidedefinition[GO:0070301]  
1
  • BHF-UCL
Cellular response to laminar fluid shear stressdefinition[GO:0071499]  
2
  • BHF-UCL
Cellular response to transforming growth factor beta stimulusdefinition[GO:0071560]  
1
  • UniProtKB
Negative regulation of cAMP catabolic processdefinition[GO:0030821]  
1
  • BHF-UCL
Negative regulation of cyclic-nucleotide phosphodiesterase activitydefinition[GO:0051344]  
1
  • BHF-UCL
Negative regulation of endothelial cell apoptotic processdefinition[GO:2000352]  
1
  • BHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240]  
1
  • BHF-UCL
Negative regulation of heterotypic cell-cell adhesiondefinition[GO:0034115]  
1
  • BHF-UCL
Negative regulation of inflammatory responsedefinition[GO:0050728]  
1
  • BHF-UCL
Negative regulation of NFAT protein import into nucleusdefinition[GO:0051534] silver  
1
  • Ortholog Compara
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathwaydefinition[GO:1902176]  
1
  • BHF-UCL
Negative regulation of response to cytokine stimulusdefinition[GO:0060761]  
1
  • BHF-UCL
Peptidyl-serine phosphorylationdefinition[GO:0018105] silver  
1
  • Ortholog Compara
Positive regulation of protein metabolic processdefinition[GO:0051247]  
1
  • BHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • BHF-UCL
Positive regulation of transcription from RNA polymerase II promoter in response to stressdefinition[GO:0036003]  
1
  • BHF-UCL
Regulation of angiogenesisdefinition[GO:0045765] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.24: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
It is regulated in the following manner
Activated by tyrosine and threonine phosphorylation (By similarity). Activated in response to hyperosmolarity, hydrogen peroxide, and epidermal growth factor (EGF).  
3
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Gap junction  hsa04540+5598  
GnRH signaling pathway  hsa04912+5598  
MAPK signaling pathway  hsa04010+5598  
Neurotrophin signaling pathway  hsa04722+5598  
According to Reactome, this protein belongs to the following pathways:
ERK/MAPK targets  REACT_12599  
ERKs are inactivated  REACT_12436  
Gastrin-CREB signalling pathway via PKC and MAPK  REACT_120966  
Senescence-Associated Secretory Phenotype (SASP)  REACT_169168  
Signalling to ERK5  REACT_12020  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Differentiation  definition   [KW-0221]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAPK7
GenomeRNAi: 5598
PRO: PR:Q13164
Chemistry
GuidetoPHARMACOLOGY: 2093